{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:25:39Z","timestamp":1791278739606,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,9,2]],"date-time":"2005-09-02T00:00:00Z","timestamp":1125619200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the expression profiles of a large number of genes within typical vasculitic nerve lesions in patients with mixed cryoglobulinemia (MC) vasculitis in order to better characterize the molecules involved in cellular tissue activation and trafficking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The quantitative expression of 19 genes coding for cytokines, chemokines, and their receptors in the nerve lesions of 9 patients with hepatitis C virus (HCV)\u2013associated MC vasculitis, 7 with idiopathic polyarteritis nodosa (PAN) (rheumatic disease controls), and 8 patients with noninflammatory idiopathic neuropathy (noninflammatory neuropathy controls) was assessed using a real\u2010time reverse transcriptase\u2013polymerase chain reaction procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the noninflammatory controls, HCV\u2010MC vasculitis patients had a significantly higher expression of Th1 cytokines in vasculitic nerve lesions (mean \u00b1 SEM fold increase 33.7 \u00b1 11.6 for interferon\u2010\u03b3 and 7.2 \u00b1 1.9 for tumor necrosis factor \u03b1), whereas Th2 cytokines were absent (interleukin\u20104 [IL\u20104], IL\u20105, and IL\u201013) or were not significantly different (IL\u201010). Chemokines involved in T cell and monocyte trafficking were also significantly up\u2010regulated in the HCV\u2010MC vasculitis patients (mean \u00b1 SEM fold increase 27.4 \u00b1 8.3 for macrophage inflammatory protein 1\u03b1 [MIP\u20101\u03b1], 19.9 \u00b1 5.7 for MIP\u20101\u03b2, and 7.2 \u00b1 1.5 for CXCR3). Compared with patients with idiopathic PAN, there was a trend toward higher expression of MIP\u20101\u03b1 and CXCR3 in HCV\u2010MC vasculitis patients (mean \u00b1 SEM fold increase 27.4 \u00b1 8.3 versus 5.3 \u00b1 3.4 for MIP\u20101\u03b1 and 7.2 \u00b1 1.5 versus 2.5 \u00b1 0.9 for CXCR3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study is the first to demonstrate a role of cellular immunity and Th1 lymphocytes in the pathogenesis of HCV\u2010MC vasculitic nerve lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.21270","type":"journal-article","created":{"date-parts":[[2005,9,2]],"date-time":"2005-09-02T16:19:25Z","timestamp":1125677965000},"page":"2917-2925","source":"Crossref","is-referenced-by-count":66,"title":["Involvement of chemokines and type 1 cytokines in the pathogenesis of hepatitis C virus\u2013associated mixed cryoglobulinemia vasculitis neuropathy"],"prefix":"10.1002","volume":"52","author":[{"given":"David","family":"Saadoun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Bieche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Maisonobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik","family":"Asselah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Laurendeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Charles","family":"Piette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Vidaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Cacoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,9,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199211193272104"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200001000-00005"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199910)42:10<2204::AID-ANR24>3.0.CO;2-D"},{"key":"e_1_2_6_5_2","first-page":"889","article-title":"Peripheral neuropathy in mixed cryoglobulinemia: clinical and electrophysiologic investigations","volume":"19","author":"Ferri C","year":"1992","journal-title":"J Rheumatol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000044399.71601.EA"},{"key":"e_1_2_6_7_2","first-page":"109","article-title":"Systemic vasculitis in patients with hepatitis C","volume":"28","author":"Cacoub P","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.9.1267"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.11.034"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00353-7"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.08.011"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(01)00277-1"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/84219"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/84205"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/84209"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370206"},{"key":"e_1_2_6_17_2","first-page":"1652","article-title":"Identification of CGA as a novel estrogen receptor\u2010responsive gene in breast cancer: an outstanding candidate marker to predict the response to endocrine therapy","volume":"61","author":"Bieche I","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780090710"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.6.2970"},{"key":"e_1_2_6_20_2","first-page":"920","article-title":"Neurological manifestations in cryoglobulinemia","volume":"158","author":"Maisonobe T","year":"2002","journal-title":"Rev Neurol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(96)00191-9"},{"issue":"9","key":"e_1_2_6_22_2","first-page":"S390","article-title":"Oligoclonal expansions of activated CD4+ T cell in HCV mixed cryoglobulinemia\u2010related vasculitis patients","volume":"48","author":"Saadoun D","year":"2003","journal-title":"Arthritis Rheum"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2598"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200109)44:9<2118::AID-ART364>3.0.CO;2-X"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1996.d01-639.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.001045"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00108-6"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.21270","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.21270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T21:17:13Z","timestamp":1696972633000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.21270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1002\/art.21270"],"URL":"https:\/\/doi.org\/10.1002\/art.21270","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}