{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:37:21Z","timestamp":1780472241035,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T00:00:00Z","timestamp":1130371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize the articular manifestations of cat\u2010scratch disease (CSD) and to evaluate the long\u2010term clinical outcome of those manifestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A community\u2010 and hospital\u2010based surveillance study of CSD was conducted in Israel between 1991 and 2002. CSD was defined as present in a patient when a compatible clinical syndrome and a positive confirmatory finding of <jats:italic>Bartonella henselae<\/jats:italic> (by serology and\/or polymerase chain reaction) were identified. CSD patients with arthropathy (arthritis\/arthralgia) that limited or precluded usual activities of daily living constituted the study group. Patients were followed up until \u22656 weeks after resolution of symptoms, or if symptoms persisted, for \u226512 months. CSD patients without arthropathy served as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 841 CSD patients, 24 (2.9%) had rheumatoid factor\u2013negative arthropathy that was often severe and disabling. Both univariate and multivariate analyses identified female sex (67% of arthropathy patients versus 40% of controls; relative risk [RR] 2.5, <jats:italic>P<\/jats:italic> = 0.047), age older than 20 years (100% of arthropathy patients versus 43% of controls; RR 4.9, <jats:italic>P<\/jats:italic> = 0.001), and erythema nodosum (21% of arthropathy patients versus 2% of controls; RR 7.9, <jats:italic>P<\/jats:italic> = 0.001) as variables significantly associated with arthropathy. Knee, wrist, ankle, and elbow joints were most frequently affected. Ten patients (42%) had severe arthropathy in the weight\u2010bearing joints, which substantially limited their ability to walk, and 4 of these patients were hospitalized. All of the patients had regional lymphadenopathy, 37.5% had nocturnal joint pain, and 25% had morning stiffness. Nineteen patients (79.2%) recovered after a median duration of 6 weeks (range 1\u201324 weeks), whereas 5 patients (20.8%) developed chronic disease persisting 16\u201353 months (median 30 months) after the onset of arthropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first comprehensive study of arthropathy in CSD. CSD\u2010associated arthropathy is an uncommon syndrome affecting mostly young and middle\u2010age women. It is often severe and disabling, and may take a chronic course.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.21411","type":"journal-article","created":{"date-parts":[[2005,10,28]],"date-time":"2005-10-28T00:49:32Z","timestamp":1130460572000},"page":"3611-3617","source":"Crossref","is-referenced-by-count":62,"title":["Cat\u2010scratch disease\u2013associated arthropathy"],"prefix":"10.1002","volume":"52","author":[{"given":"Michael","family":"Giladi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Maman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphna","family":"Paran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Bickels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Comaneshter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boaz","family":"Avidor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merav","family":"Varon\u2010Graidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Ephros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomo","family":"Wientroub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.2.203"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.3.390"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/014107688908200819"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.70.820.147"},{"key":"e_1_2_6_6_2","first-page":"1263","article-title":"Bartonella henselae infection mimicking systemic onset juvenile chronic arthritis in a 2 1\/2\u2010year\u2010old girl","volume":"23","author":"Hayem F","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003930050074"},{"key":"e_1_2_6_8_2","first-page":"184","article-title":"Rheumatic manifestations of Bartonella infection in 2 children","volume":"29","author":"Al\u2010Matar MJ","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_9_2","first-page":"76","article-title":"La maladie des griffes de chat","volume":"66","author":"Debr'e R","year":"1950","journal-title":"Bull Mem Soc Med Hop Paris"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/324162"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/378738"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1128\/jcm.35.8.1924-1930.1997","article-title":"Molecular diagnosis of cat scratch disease: a two\u2010step approach","volume":"35","author":"Avidor B","year":"1997","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1309\/Y5WN-8DFD-WLVT-KKAD"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.8.3462-3468.2004"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1985.02140130062031"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0891-5520(20)30132-X","article-title":"Cat scratch disease","volume":"1","author":"Moriarty RA","year":"1987","journal-title":"Infect Dis Clin North Am"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.83.12.1707"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199307013290102"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92032-B"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.32.4.942-948.1994"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(02)00081-9"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.2.348-369.2004"},{"key":"e_1_2_6_23_2","first-page":"499","article-title":"Reactive arthritis (Reiter's syndrome)","volume":"60","author":"Barth WF","year":"1999","journal-title":"Am Fam Physician"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198312293092604"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70037-5"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199910)42:10<2239::AID-ANR29>3.0.CO;2-L"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.4.916"}],"container-title":["Arthritis &amp; 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