{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T23:57:19Z","timestamp":1779321439364,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,29]],"date-time":"2005-12-29T00:00:00Z","timestamp":1135814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the association of baseline concentrations of serum cartilage oligomeric matrix protein (COMP) and serum N\u2010telopeptide crosslinks (NTX) with the development and progression of radiographic hip osteoarthritis (RHOA) in elderly women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pelvic radiographs were obtained a mean of 8.3 years apart from white women \u226565 years of age enrolled in the Study of Osteoporotic Fractures. Random sampling from a cohort of 5,928 subjects was performed, with subjects (\u223c200 per group) assigned to nested case\u2013control studies, one focusing on RHOA incidence and the other on RHOA progression. Baseline serum levels of COMP and NTX were measured by enzyme\u2010linked immunosorbent assay in duplicate. Odds ratios (ORs) and 95% confidence intervals (95% CIs), indicating the likelihood of baseline serum COMP and NTX levels to be predictive of the development or progression of RHOA, were calculated using logistic regression analysis, with adjustment for potential covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, incident cases of RHOA were associated with higher serum levels of COMP and NTX (<jats:italic>P<\/jats:italic> &lt; 0.05 for each) compared with the no RHOA control group. Higher baseline serum COMP and NTX levels were associated with an increased risk of incident RHOA compared with the no RHOA group, with an adjusted OR of 1.31 per SD increase in COMP (95% CI 1.02\u20131.68) and adjusted OR of 1.38 per SD increase in NTX (95% CI 1.07\u20131.79). In this community\u2010based cohort, progression of RHOA was modest. However, there was a trend toward increased risk of RHOA progression with higher baseline COMP and NTX levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data suggest that serum levels of COMP and NTX are modest risk markers for the development of RHOA in a community\u2010based cohort of elderly white women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.21527","type":"journal-article","created":{"date-parts":[[2005,12,29]],"date-time":"2005-12-29T18:17:17Z","timestamp":1135880237000},"page":"236-243","source":"Crossref","is-referenced-by-count":47,"title":["Association of higher levels of serum cartilage oligomeric matrix protein and N\u2010telopeptide crosslinks with the development of radiographic hip osteoarthritis in elderly women"],"prefix":"10.1002","volume":"54","author":[{"given":"A.","family":"Kelman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Krumme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nevitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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