{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:59:44Z","timestamp":1791248384155,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,29]],"date-time":"2005-12-29T00:00:00Z","timestamp":1135814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the cellular mediators of antigen\u2010induced arthritis (AIA) and the relative contribution of members of the interleukin\u20106 (IL\u20106) family and tumor necrosis factor (TNF) in AIA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>AIA was induced in mice deficient in T and B lymphocytes, IL\u20106 (IL\u20106<jats:sup>\u2212\/\u2212<\/jats:sup>), TNF (TNF<jats:sup>\u2212\/\u2212<\/jats:sup>), IL\u201011 receptor, and oncostatin M receptor, by immunization with methylated bovine serum albumin (mBSA) followed 7 days later by intraarticular injection of mBSA. Arthritis severity was assessed histologically, and T lymphocyte responses were assessed in vitro. Anti\u2010TNF neutralizing antibody was administered to wild\u2010type mice during AIA. Bone marrow osteoclasts were generated in vitro via culture with RANKL and macrophage colony\u2010stimulating factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AIA was dependent on CD4+ T lymphocytes, but not CD8+ T lymphocytes or B cells. IL\u20106<jats:sup>\u2212\/\u2212<\/jats:sup> mice had reduced AIA severity and fewer osteoclasts at sites of bone erosion. This protective effect was not seen with a deficiency of other IL\u20106 family members and was similar to that in TNF<jats:sup>\u2212\/\u2212<\/jats:sup> mice or wild\u2010type mice receiving TNF blockade treatment. IL\u20106<jats:sup>\u2212\/\u2212<\/jats:sup> CD4+ T lymphocytes from draining lymph nodes had reduced antigen\u2010induced proliferation and produced less IL\u201017 and less RANKL, relative to osteoprotegerin, than cells from wild\u2010type mice. Bone marrow from IL\u20106<jats:sup>\u2212\/\u2212<\/jats:sup> mice generated fewer osteoclasts in vitro than bone marrow from either wild\u2010type or TNF<jats:sup>\u2212\/\u2212<\/jats:sup> mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AIA is driven by CD4+ T lymphocytes. IL\u20106 is an important mediator of bone destruction in AIA because it regulates T lymphocyte production of key osteoclastogenic cytokines and inflammation\u2010induced bone marrow osteoclast differentiation. These findings have implications for reducing bone and joint damage in rheumatoid arthritis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.21537","type":"journal-article","created":{"date-parts":[[2005,12,29]],"date-time":"2005-12-29T18:24:37Z","timestamp":1135880677000},"page":"158-168","source":"Crossref","is-referenced-by-count":227,"title":["Interleukin\u20106 modulates production of T lymphocyte\u2013derived cytokines in antigen\u2010induced arthritis and drives inflammation\u2010induced osteoclastogenesis"],"prefix":"10.1002","volume":"54","author":[{"given":"Peter K. K.","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian M. 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