{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:38:40Z","timestamp":1768721920735,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2005,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe patterns of adherence to nonsteroidal antiinflammatory drugs (NSAIDs) in newly diagnosed patients with juvenile rheumatoid arthritis (JRA), and to examine demographic and disease\u2010related variables as potential predictors of adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adherence to NSAIDs was monitored in 48 children with JRA (mean age 8.6 years) over 28 consecutive days using an electronic monitoring device. Measures of disease activity (active joint counts, morning stiffness) and demographics (age, sex, ethnicity, socioeconomic status) were also obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using an 80% adherence cut point, 25 (52%) patients were classified as adherent and 23 (48%) as nonadherent. There was considerable variability across patients, with full adherence (taking all doses on time) ranging from 0 to 100% of the monitored days. Logistic regression showed that active joint count and socioeconomic status were the only significant predictors. Both were positively related to adherence. The model correctly classified 70.5% of patients as either adherent or nonadherent (Cox and Snell R<jats:sup>2<\/jats:sup> = 0.295, <jats:italic>P<\/jats:italic> = 0.0005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children newly diagnosed with JRA are more likely to adhere to an NSAID regimen if they have a greater number of active joints or their families have higher socioeconomic status. The former finding suggests that children's adherence is symptom\u2010driven, while the latter suggests that families of lower socioeconomic status deserve special attention to address adherence issues.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.21603","type":"journal-article","created":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T21:50:32Z","timestamp":1133992232000},"page":"905-910","source":"Crossref","is-referenced-by-count":46,"title":["Electronically monitored adherence to medications by newly diagnosed patients with juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"53","author":[{"given":"Michael A.","family":"Rapoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Belmont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol B.","family":"Lindsley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy Y.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Textbook of pediatric rheumatology","author":"Cassidy JT","year":"2005"},{"key":"e_1_2_5_3_2","volume-title":"Adherence to pediatric medical regimens","author":"Rapoff MA","year":"1999"},{"key":"e_1_2_5_4_2","first-page":"434","article-title":"Compliance with salicylate therapy in adolescents with juvenile rheumatoid arthritis","volume":"135","author":"Litt IF","year":"1981","journal-title":"Am J Dis Child"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1542\/peds.69.1.15","article-title":"Role of self\u2010esteem and autonomy in determining medication compliance among adolescents with juvenile rheumatoid arthritis","volume":"69","author":"Litt IF","year":"1982","journal-title":"Pediatrics"},{"key":"e_1_2_5_6_2","first-page":"267","article-title":"Improving compliance with medical regimens: case study with juvenile rheumatoid arthritis","volume":"65","author":"Rapoff MA","year":"1984","journal-title":"Arch Phys Med Rehabil"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1790010105"},{"key":"e_1_2_5_8_2","first-page":"439","article-title":"Educational and behavioral strategies for improving medication compliance in juvenile rheumatoid arthritis","volume":"69","author":"Rapoff MA","year":"1988","journal-title":"Arch Phys Med Rehabil"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1790020313"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/14.3.389"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-172X.2002.00389.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980215)17:3<251::AID-SIM762>3.0.CO;2-A"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199549030-00001"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.1.60"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.21.6.620"},{"issue":"2","key":"e_1_2_5_16_2","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"Brewer EJ","year":"1997","journal-title":"Arthritis Rheum"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0148-9062(75)90418-0"},{"key":"e_1_2_5_18_2","first-page":"11","volume-title":"Compliance in health care","author":"Sackett DL","year":"1979"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200306010-00016"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/02770909809075667"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.50.12.1274"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62557-4"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)80190-4"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00869109"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/15.4.543"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.8.2.146"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.2307\/583760"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.3109\/02770907809106598"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.53.100901.135233"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.128.2.295"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162086599"},{"key":"e_1_2_5_32_2","first-page":"23","volume-title":"Compliance in health care","author":"Gordis L","year":"1979"}],"container-title":["Arthritis Care &amp; 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