{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:14:21Z","timestamp":1791670461204,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,2,6]],"date-time":"2006-02-06T00:00:00Z","timestamp":1139184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2006,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Patients with chronic periaortitis (CP) often show clinical and laboratory findings of a systemic autoimmune disorder. The aim of the present study was to investigate the role of the HLA system in CP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Low\u2010resolution genotyping for HLA\u2013A, HLA\u2013B, and HLA\u2013DRB1 loci and genotyping of TNFA(\u2010238)A\/G and TNFA(\u2010308)A\/G single nucleotide polymorphisms were performed in 35 consecutive patients with CP and 350 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The HLA\u2013DRB1*03 allele frequency was strikingly higher in patients with CP than in controls (24.28% versus 9.14%; \u03c7<jats:sup>2<\/jats:sup> = 15.50, <jats:italic>P<\/jats:italic> = 0.000084, corrected <jats:italic>P<\/jats:italic> [<jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub>] = 0.0012, odds ratio [OR] 3.187, 95% confidence interval [95% CI] 1.74\u20135.83); the HLA\u2013B*08 allele frequency was also higher in patients than in controls (17.14% versus 6.28%; \u03c7<jats:sup>2<\/jats:sup>=11.12, <jats:italic>P<\/jats:italic> = 0.0008, <jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> = 0.0269, OR 3.085, 95% CI 1.54\u20136.16). The A*01 allele frequency was significantly different (<jats:italic>P<\/jats:italic> = 0.0463), but the statistical significance was lost after correction for multiple testing (<jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> = 0.5088). TNFA(\u2010238)A allele and TNFA(\u2010308)A allele frequencies were not significantly different (<jats:italic>P<\/jats:italic> = 0.512 and <jats:italic>P<\/jats:italic> = 0.445, respectively). Comparison of the main clinical and laboratory findings suggestive of a systemic autoimmune disease (e.g., acute\u2010phase reactants, constitutional symptoms, other autoimmune diseases associated with CP) between the HLA\u2013DRB1*03\u2013positive and the HLA\u2013DRB1*03\u2013negative patients showed that the former group had significantly higher levels of C\u2010reactive protein (<jats:italic>P<\/jats:italic> = 0.045) at disease onset, although this difference was not statistically significant after correction for multiple tests (<jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> = 0.369).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The HLA system plays a role in susceptibility to CP. The strong association between CP and HLA\u2013DRB1*03, an allele linked to a wide range of autoimmune conditions, further supports the view that CP may represent a clinical manifestation of an autoimmune disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.21698","type":"journal-article","created":{"date-parts":[[2006,2,7]],"date-time":"2006-02-07T00:17:11Z","timestamp":1139271431000},"page":"126-130","source":"Crossref","is-referenced-by-count":96,"title":["Chronic periaortitis and HLA\u2013DRB1*03: Another clue to an autoimmune origin"],"prefix":"10.1002","volume":"55","author":[{"given":"Davide","family":"Martorana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Vaglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Greco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Zanetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Moroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Salvarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Savi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Buzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tauro M.","family":"Neri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000145517.83972.40"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1990.tb01541.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(86)90070-5"},{"key":"e_1_2_6_5_2","first-page":"383","article-title":"Serum antibodies to oxidized low\u2010density lipoprotein and ceroid in chronic periaortitis","volume":"114","author":"Parums DV","year":"1990","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00056-1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/S0022-5347(17)50607-2","article-title":"Idiopathic retroperitoneal fibrosis in twins","volume":"131","author":"Duffy PG","year":"1984","journal-title":"J Urol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(87)80715-7"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009143431106"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.66.4.562"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1998.tb02277.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20360"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a000179"},{"key":"e_1_2_6_14_2","unstructured":"UitenbroekDG. 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