{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:01:14Z","timestamp":1791302474671,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,30]],"date-time":"2006-01-30T00:00:00Z","timestamp":1138579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>B lymphocytes are emerging as important elements in the events leading to joint destruction in rheumatoid arthritis (RA). However, B lymphocytes have not been studied in rheumatoid arthritis (RA)\u2013associated lung disease. We performed a morphologic and quantitative analysis of B lymphocytes and plasma cells in RA\u2010associated interstitial pneumonia (IP) in comparison with idiopathic IP and normal lungs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Open\u2010lung biopsy specimens from patients with RA\u2010associated IP (n = 18), patients with idiopathic IP (n = 21), and control subjects (n = 11) were stained with antibodies to CD20 and CD138. Morphologic patterns of stained specimens were characterized and staining was quantified using computer\u2010assisted image analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In RA\u2010associated IP, marked follicular B cell hyperplasia was detected, which was limited almost entirely to peribronchiolar lymphoid aggregates. Plasma cells were also present in large numbers, but showed a more diffuse tissue infiltration. Quantification of B cells demonstrated higher cellularity in RA\u2010associated IP (median 2.0%, interquartile range [IQR] 1.0\u20135.7) as compared with idiopathic IP (0.9%, IQR 0.5\u20132.1). Control specimens showed a significantly smaller number of B cells compared with both diseases (0.4%, IQR 0.1\u20131.3). In RA patients who were smokers and in those who were male, the proportion of CD20+ tissue areas further increased to 4.3% (IQR 1.0\u20135.8) and 3.9% (IQR 0.7\u20136.9), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrated a significant follicular B cell hyperplasia in RA\u2010associated IP. The differences between RA\u2010associated IP and idiopathic IP imply a differential emphasis of B cell\u2013mediated mechanisms in the 2 diseases despite radiologic and histologic similarities and provide a rationale for studying functional aspects of B cell involvement in the pathogenesis of RA\u2010associated IP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.21758","type":"journal-article","created":{"date-parts":[[2006,1,30]],"date-time":"2006-01-30T22:26:48Z","timestamp":1138660008000},"page":"635-641","source":"Crossref","is-referenced-by-count":86,"title":["Morphologic and quantitative assessment of CD20+ B cell infiltrates in rheumatoid arthritis\u2013associated nonspecific interstitial pneumonia and usual interstitial pneumonia"],"prefix":"10.1002","volume":"54","author":[{"given":"Sarah R.","family":"Atkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Turesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery L.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry D.","family":"Tazelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay H.","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric 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