{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:28:17Z","timestamp":1791300497436,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T00:00:00Z","timestamp":1148601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Autoantibodies to aminoacyl transfer RNA synthetases, such as histidyl (Jo\u20101), threonyl (PL\u20107), alanyl (PL\u201012), glycyl (EJ), and isoleucyl (OJ), are closely associated with a subset of patients with polymyositis\/dermatomyositis (PM\/DM) complicated by interstitial lung disease (ILD). Anti\u2013Jo\u20101 is by far the most common, found in 15\u201325% of patients with PM\/DM, whereas the other types are found in only \u223c3% of these patients. In this study, the clinical associations of these autoantibodies in Japanese patients with PM\/DM were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The diagnoses of PM\/DM and amyopathic DM (ADM) were based on the Bohan and Peter criteria and Sontheimer's definition, respectively. Sera from 36 Japanese patients with PM\/DM (13 with PM, 20 with DM, 3 with ADM) were screened by immunoprecipitation and by enzyme\u2010linked immunosorbent assay (for Jo\u20101). Clinical and laboratory data were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequencies of autoantibodies to Jo\u20101 (22%) and to EJ, OJ, and PL\u201012 (3\u20136%) were similar to those found in previous studies, including studies of Japanese subjects. However, anti\u2013PL\u20107 was found in 17% of patients, in contrast to a frequency of 1\u20134% in previous studies (<jats:italic>P<\/jats:italic> &lt; 0.02\u20130.0002). The 6 anti\u2013PL\u20107\u2013positive patients were not related, and no skewing in year or month of disease development, place of residence or work, or occupation was found. All patients had ILD, consistent with the clinical features of antisynthetase\u2010positive patients. The patients with anti\u2013PL\u20107 had lower serum muscle enzyme levels and milder muscle weakness (<jats:italic>P<\/jats:italic> &lt; 0.05) compared with anti\u2013Jo\u20101\u2013positive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2013PL\u20107 was found at an unusually high frequency in this group of Japanese patients with myositis. Although anti\u2013PL\u20107, similar to anti\u2013Jo\u20101, is associated with PM\/DM with ILD, muscle involvement in the patients with anti\u2013PL\u20107 appeared to be milder than that in the anti\u2013Jo\u20101 subset.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.21883","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T16:27:57Z","timestamp":1148660877000},"page":"2004-2009","source":"Crossref","is-referenced-by-count":102,"title":["Unusually high frequency of autoantibodies to PL\u20107 associated with milder muscle disease in Japanese patients with polymyositis\/dermatomyositis"],"prefix":"10.1002","volume":"54","author":[{"given":"Yoshioki","family":"Yamasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiko","family":"Nozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Akaogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Chin Loy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward K. L.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Westley H.","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200011000-00001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310408"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390910"},{"key":"e_1_2_6_5_2","first-page":"105","article-title":"Cellular protein and RNA antigens in autoimmune disease","volume":"2","author":"Bernstein RM","year":"1984","journal-title":"Mol Biol Med"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350415"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199111000-00002"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.160.2.420"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199911000-00005"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290501"},{"key":"e_1_2_6_15_2","first-page":"933","volume-title":"Manual of clinical laboratory immunology","author":"Reeves WH","year":"2001"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292704"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960161212"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.1.163"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280303"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(02)00029-7"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(96)80026-6"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/77.1.1019"},{"key":"e_1_2_6_23_2","first-page":"609","article-title":"Clinical characteristics of Japanese patients with anti\u2010PL\u20107 (anti\u2010threonyl\u2010tRNA synthetase) autoantibodies","volume":"23","author":"Sato S","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_24_2","first-page":"1094","article-title":"Incidence of inflammatory myopathies in Victoria, Australia, and evidence of spatial clustering","volume":"26","author":"Patrick M","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341108"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.21883","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.21883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T14:50:38Z","timestamp":1697467838000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.21883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,26]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1002\/art.21883"],"URL":"https:\/\/doi.org\/10.1002\/art.21883","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,26]]}}}