{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:32:47Z","timestamp":1791174767493,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,26]],"date-time":"2006-06-26T00:00:00Z","timestamp":1151280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify B cell subpopulations participating in the lymphocyte infiltrate of salivary glands from patients with primary Sj\u00f6gren's syndrome. A special emphasis was placed on those B lymphocytes included in the ectopic germinal centers (GCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The presence of B cells in salivary glands and their polyclonality were ascertained by phenotyping and reverse transcription\u2013polymerase chain reaction in salivary gland samples from 18 patients. Their phenotype was thoroughly analyzed using a number of double\u2010staining combinations. The results obtained in tissue sections were confirmed by fluorescence\u2010activated cell sorting analysis of B cells eluted from salivary glands, and these findings were compared with those in tonsils.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Memory\u2010type B cells were defined as CD20+,CD27+ and were seen in all specimens, whereas GCs were found in only 7 specimens. Furthermore, B cells found in these GCs lacked certain characteristics of centroblasts and centrocytes. Instead, they fulfilled the criteria for transitional type II (TII) B cells and resembled marginal\u2010zone B cells. BAFF (the assistance of which is required for proper transformation of transitional TI B cells into transitional TII B cells) accumulated adjacent to transitional and marginal\u2010zone\u2013like B lymphocytes. Further evidence for the involvement of BAFF came from the expression of its receptors on infiltrating B cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These transitional TII and marginal\u2010zone\u2013like B cells are probably instrumental in the local production of autoantibodies and possibly influential in the ensuing destruction of epithelial cells.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.21936","type":"journal-article","created":{"date-parts":[[2006,6,27]],"date-time":"2006-06-27T00:06:04Z","timestamp":1151366764000},"page":"2280-2288","source":"Crossref","is-referenced-by-count":123,"title":["Identification of transitional type II B cells in the salivary glands of patients with Sj\u00f6gren's 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