{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T06:12:56Z","timestamp":1769926376981,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,7,25]],"date-time":"2006-07-25T00:00:00Z","timestamp":1153785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To longitudinally investigate serum and synovial fluid (SF) levels of RANTES and monocyte chemoattractant protein 1 (MCP\u20101) as well as in vitro migration of mononuclear cells toward SF in patients with juvenile rheumatoid arthritis (JRA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum and SF levels of RANTES and MCP\u20101 were determined by enzyme\u2010linked immunosorbent assay. Chemotaxis was performed using the modified Boyden chamber method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum RANTES levels were significantly increased in all onset types of JRA, with the highest levels present in systemic\u2010onset JRA. Serum MCP\u20101 levels were significantly elevated in patients with systemic\u2010onset JRA and were associated with current systemic features. Although serum levels of RANTES and MCP\u20101 decreased significantly after treatment, RANTES and MCP\u20101 levels during disease remission were still significantly higher in JRA patients than in controls. A relationship was found between serum RANTES levels during remission and the duration of clinical remission, with low levels being associated with prolonged clinical remission and high levels with shorter clinical remission. Serum RANTES levels correlated with C\u2010reactive protein concentrations, hemoglobin values, white blood cell (WBC) counts, and platelet counts, whereas serum MCP\u20101 levels correlated with WBC counts and serum ferritin levels. Levels of RANTES and MCP\u20101 in SF were elevated as compared with levels in serum. SF chemotactic activity for mononuclear leukocytes was significantly inhibited by either anti\u2010RANTES or anti\u2013MCP\u20101 antibody.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RANTES is a key molecule in the pathogenesis of all onset groups of JRA, whereas MCP\u20101 is particularly important in systemic\u2010onset JRA. Serum levels of these CC chemokines represent more highly sensitive markers of disease activity than conventional markers of inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.21962","type":"journal-article","created":{"date-parts":[[2006,7,25]],"date-time":"2006-07-25T22:46:43Z","timestamp":1153867603000},"page":"2585-2593","source":"Crossref","is-referenced-by-count":45,"title":["RANTES and monocyte chemoattractant protein 1 as sensitive markers of disease activity in patients with juvenile rheumatoid arthritis: A six\u2010year longitudinal study"],"prefix":"10.1002","volume":"54","author":[{"given":"Tsung\u2010Chieh","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Ling","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai\u2010Chu","family":"See","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang\u2010Shiou","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010I","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin\u2010Kan","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010Long","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802123380706"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(97)00075-8"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/33340"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80165-X"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002960100104"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2172"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199705)182:1<106::AID-PATH816>3.0.CO;2-A"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.1.131"},{"key":"e_1_2_5_10_2","first-page":"419","article-title":"Relationship between serum RANTES levels and radiological progression in rheumatoid arthritis patients treated with methotrexate","volume":"17","author":"Boiardi L","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115950"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360605"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1993.1153"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016345032580"},{"issue":"2","key":"e_1_2_5_15_2","first-page":"195","article-title":"Current proposed revision of the JRA criteria","volume":"20","author":"JRA Criteria Subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290216"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.2.167"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200201)46:1<232::AID-ART10059>3.0.CO;2-B"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-5323(02)00124-0"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1506"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2003.00438.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009748709102914"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.5.2601"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/347669a0"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.5530120114"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1998.4590"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1422"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(00)01812-3"},{"key":"e_1_2_5_29_2","first-page":"425","article-title":"Interleukin 8 and monocyte chemoattractant protein\u20101 in patients with juvenile rheumatoid arthritis. 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