{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T19:45:58Z","timestamp":1793562358701,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T00:00:00Z","timestamp":1149033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2006,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The frequency of many adverse events (AEs) associated with low\u2010dose glucocorticoid use is unclear. We sought to determine the prevalence of glucocorticoid\u2010associated AEs in a large US managed care population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using linked administrative and pharmacy claims, adults receiving \u226560 days of glucocorticoids were identified. These individuals were surveyed about glucocorticoid use and symptoms of 8 AEs commonly attributed to glucocorticoid use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 6,517 eligible glucocorticoid users identified, 2,446 (38%) returned the mailed survey. Respondents were 29% men with a mean \u00b1 SD age of 53 \u00b1 14 years; 79% were white and 13% were African American. Respondents had a mean \u00b1 SD of 7 \u00b1 3 comorbid conditions and were prescribed a mean \u00b1 SD prednisone\u2010equivalent dosage of 16 \u00b1 14 mg\/day. More than 90% of individuals reported at least 1 AE associated with glucocorticoid use; 55% reported that at least 1 AE was very bothersome. Weight gain was the most common self\u2010reported AE (70% of the individuals), cataracts (15%) and fractures (12%) were among the most serious. After multivariable adjustment, all AEs demonstrated a strong dose\u2010dependent association with cumulative glucocorticoid use. Among users of low\u2010dose therapy (\u22647.5 mg of prednisone per day), increasing duration of use was significantly associated with acne, skin bruising, weight gain, and cataracts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of 8 commonly attributed self\u2010reported glucocorticoid\u2010associated AEs was significantly associated with cumulative and average glucocorticoid dose in a dose\u2010dependent fashion. Physicians should be vigilant for glucocorticoid\u2010related AEs and should counsel patients about possible risks, even among low\u2010dose long\u2010term users.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.21984","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T20:17:33Z","timestamp":1149106653000},"page":"420-426","source":"Crossref","is-referenced-by-count":506,"title":["Population\u2010based assessment of adverse events associated with long\u2010term glucocorticoid use"],"prefix":"10.1002","volume":"55","author":[{"given":"Jeffrey R.","family":"Curtis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew O.","family":"Westfall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroan","family":"Allison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes 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