{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:01:16Z","timestamp":1791331276292,"version":"4.3.1"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T00:00:00Z","timestamp":1153872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine if levels of endogenous estrogen or estrogen metabolites are associated with an increased risk of developing knee osteoarthritis (OA) in women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum estradiol (E<jats:sub>2<\/jats:sub>) and 2 urinary estrogen metabolites (2\u2010hydroxyestrone and 16\u03b1\u2010hydroxyestrone) with radiographically defined prevalent and incident knee OA in 842 white and African American women from the Southeast Michigan Arthritis Cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age and body mass index (BMI) of women in the cohort were 42.3 years and 28.5 kg\/m<jats:sup>2<\/jats:sup>, respectively. Women who developed radiographically defined knee OA had significantly greater odds of having baseline endogenous early follicular phase estradiol concentrations in the lowest tertile (&lt;47 pg\/ml; odds ratio [OR] 1.88, 95% confidence interval [95% CI] 1.07\u20133.51) compared with those with estradiol concentrations in the middle tertile [47\u201377 pg\/ml]), after adjustment for age, BMI, and other covariates. Women who developed knee OA also had greater odds of having baseline urinary concentrations of 2\u2010hydroxyestrone in the lowest tertile (OR 2.9, 95% CI 1.49\u20135.68) compared with women with 2\u2010hydroxyestrone concentrations in the middle tertile), after adjustment for covariates. Women who developed knee OA were more likely to have a ratio of 16\u03b1\u2010hydroxyestrone to 2\u2010hydroxyestrone in the highest tertile (&gt;0.86; OR 1.86, 95% CI 1.01\u20133.44 compared with women with ratios in the 0.54\u20130.86 range), after adjustment for other covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were significant associations of lower baseline serum estradiol and urinary 2\u2010hydroxyestrone with developing knee OA in middle\u2010aged women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.22005","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T17:51:20Z","timestamp":1153936280000},"page":"2481-2487","source":"Crossref","is-referenced-by-count":111,"title":["Estradiol and its metabolites and their association with knee osteoarthritis"],"prefix":"10.1002","volume":"54","author":[{"given":"MaryFran 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