{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:06:51Z","timestamp":1791104811337,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T00:00:00Z","timestamp":1164672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate potential associations between interleukin\u201010 (IL\u201010) promoter polymorphisms and susceptibility to, and clinical features of, giant cell arteritis (GCA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 140 patients with biopsy\u2010proven GCA who were residents of Reggio Emilia, Italy, and 200 population\u2010based controls from the same geographic area were genotyped for promoter polymorphisms of the IL\u201010 gene, by molecular methods. The patients were subgrouped according to the presence or absence of polymyalgia rheumatica (PMR) and ischemic complications (any or all of the following: vision loss, jaw claudication, cerebrovascular accidents, or aortic arch syndrome).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The distribution of the C\/A 592 genotype differed significantly between the GCA patients and the controls (<jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> = 0.003). Carriers of the A592 allele (A\/A or C\/A) were significantly more frequent among the GCA patients than among the controls (<jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> = 0.004, odds ratio [OR] 2.0 [95% confidence interval (95% CI) 1.3\u20133.1]). Homozygosity for the A592 allele was significantly more frequent among the GCA patients than among the controls (<jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> = 0.002, OR 3.4 [95% CI 1.6\u20137.2]). The distribution of the A\/G 1082 genotype was similar in GCA patients and controls. In the haplotype analysis, the frequency of the ATA haplotype was significantly higher in GCA patients than in the controls (<jats:italic>P<\/jats:italic> = 0.0001), whereas the frequencies of the ACC and GTA haplotypes were significantly lower (<jats:italic>P<\/jats:italic> = 0.0001 for both comparisons). No significant associations were found for comparisons of GCA patients with and those without PMR or GCA patients with and those without ischemic complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings show that the \u2212592 C\/A promoter polymorphism of the IL\u201010 gene is associated with susceptibility to GCA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.22218","type":"journal-article","created":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T23:02:44Z","timestamp":1164754964000},"page":"4011-4017","source":"Crossref","is-referenced-by-count":39,"title":["Interleukin\u201010 promoter polymorphisms in giant cell arteritis"],"prefix":"10.1002","volume":"54","author":[{"given":"Luigi","family":"Boiardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Casali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Farnetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"Pipitone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Nicoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Macchioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cimino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Bajocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Grazia Catanoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pattacini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Salvarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022694"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.683"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2370.1997.tb00001.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9465"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363656"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199906)42:6<1101::AID-ANR6>3.0.CO;2-Y"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300207"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363657"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh187"},{"issue":"9","key":"e_1_2_5_11_2","first-page":"S179","article-title":"IL\u201010 polymorphisms in relation to production and rheumatoid arthritis (RA)","volume":"40","author":"Keijsers V","year":"1997","journal-title":"Arthritis Rheum"},{"key":"e_1_2_5_12_2","first-page":"520","article-title":"Geographical and genetic factors do not account for significant differences in the clinical spectrum of giant cell arteritis in southern Europe","volume":"31","author":"Gonzalez\u2010Gay MA","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_5_13_2","first-page":"205","article-title":"Polymyalgia rheumatica and giant cell arteritis: a 5\u2010year epidemiologic and clinical study in Reggio Emilia, Italy","volume":"5","author":"Salvarani C","year":"1987","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/345366"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2002.590405.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth149"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.10.6427"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.10.f53"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra055446"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200101)44:1<3::AID-ANR2>3.0.CO;2-U"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.7.4075"},{"key":"e_1_2_5_22_2","first-page":"217","article-title":"The pathogenic role of T lymphocytes in vasculitis","volume":"13","author":"Weyand CM","year":"1996","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2901"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.7.3602"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400105"},{"issue":"36","key":"e_1_2_5_26_2","first-page":"S18","article-title":"Interferon\u2010\u03b3 gene microsatellite polymorphisms in patients with biopsy\u2010proven giant cell arteritis and isolated polymyalgia rheumatica","volume":"22","author":"Gonzalez\u2010Gay MA","year":"2004","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_27_2","first-page":"431","article-title":"Lack of association between IL\u20101 cluster and TNF\u2010\u03b1 gene polymorphisms and giant cell arteritis","volume":"20","author":"Gonzalez\u2010Gay MA","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.5.1456"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364004"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363964"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2003.10.009"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2004.08.010"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-2815.2004.00183.x"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2003.174"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.019885"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2005.07.007"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200301000-00005"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-0022-4"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-004-1066-5"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.9.1025"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200101)44:1<176::AID-ANR23>3.0.CO;2-K"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.11.1117"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg420"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-004-0952-1"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.58.2.85"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001090100263"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6616(03)00211-0"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363920"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.22218","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.22218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:36:35Z","timestamp":1695947795000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.22218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,28]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1002\/art.22218"],"URL":"https:\/\/doi.org\/10.1002\/art.22218","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,28]]}}}