{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T13:17:56Z","timestamp":1774790276881,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,30]],"date-time":"2007-01-30T00:00:00Z","timestamp":1170115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the clinical and immunologic significance of autoantibodies to RNA helicase A (RHA) in patients with systemic rheumatic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study group comprised 1,119 individuals enrolled in the University of Florida Center for Autoimmune Diseases registry from 2000 to 2005. Diagnoses were based on standard criteria. Autoantibodies were analyzed by immunoprecipitation and Western blot assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anti\u2010RHA was observed in 17 (6.2%) of 276 patients with systemic lupus erythematosus (SLE), 2 patients with antiphospholipid antibodies, and 3 other patients, but anti\u2010RHA was not observed in any patient with polymyositis\/dermatomyositis, systemic sclerosis, rheumatoid arthritis, or Sj\u00f6gren's syndrome. Anti\u2010RHA was present in only 2.9% of African American patients, compared with 6.0% of white patients and 12\u201325% of patients of other races; this was in striking contrast to the frequency of anti\u2010Sm in African American patients (27.2%). Among patients with SLE, anti\u2010RHA was common in young patients (26% of those whose initial visit was at an age younger than 20 years versus 3\u20134% of those who were initially seen at ages 20\u201349 years) and at an early stage of disease (23% of those whose first clinic visit was within 1 year of disease onset versus 2\u20138% of those whose first visit was at least 1 year after disease onset). In 9 of 11 patients, levels of anti\u2010RHA decreased to &lt;10% of the initial value within 9\u201337 months, while levels of coexisting anti\u2010Ro or anti\u2010Su remained the same. New specificities developed in 2 patients (anti\u2013nuclear RNP and anti\u2010Sm, and anti\u2013ribosomal P, respectively). These data suggest that the level of anti\u2010RHA diminishes over time, and that anti\u2010RHA is regulated via a mechanism different from that for other lupus\u2010related autoantibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2010RHA is a new serologic marker for SLE. It is produced mainly in young non\u2013African Americans at an early stage of their disease. Anti\u2010RHA has a unique tendency to diminish over time. The production of anti\u2010RHA may depend on a process restricted to early SLE, or it may be highly sensitive to treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.22329","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T00:14:57Z","timestamp":1170461697000},"page":"596-604","source":"Crossref","is-referenced-by-count":49,"title":["Autoantibodies to RNA helicase A: A new serologic marker of early lupus"],"prefix":"10.1002","volume":"56","author":[{"given":"Yoshioki","family":"Yamasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonali","family":"Narain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liza","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tolga","family":"Barker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulette C.","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric S.","family":"Sobel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Segal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanno B.","family":"Richards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward K. 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