{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:19:12Z","timestamp":1790741952009,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,30]],"date-time":"2007-01-30T00:00:00Z","timestamp":1170115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Interleukin\u20101 (IL\u20101) acts via its receptors to induce gene expression that mediates protein synthesis involved in inflammation. Increased expression of IL\u20101\u03b1 and IL\u20101\u03b2 in muscle tissue from patients with polymyositis and dermatomyositis has been demonstrated. It is not known whether the reciprocal IL\u20101 receptors are expressed in human muscle tissue. The purpose of this study was to investigate the expression of IL\u20101 receptors and their ligands in muscle tissue from patients with myositis and from healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Muscle biopsy tissues from 10 patients with polymyositis or dermatomyositis and 7 healthy control subjects were investigated by immunohistochemistry using antibodies against IL\u20101 receptor type I (IL\u20101RI), IL\u20101RII, IL\u20101\u03b1, IL\u20101\u03b2, and IL\u20101 receptor antagonist (IL\u20101Ra). Quantification was performed by computerized image analysis, and localization of expression was determined by double staining using immunofluorescence and confocal microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In tissue samples from the patients, IL\u20101RI and IL\u20101RII were expressed in muscle fibers, inflammatory cells, and endothelial cells. Expression in muscle fibers was localized to the sarcolemma and nuclei. IL\u20101\u03b1 was expressed in endothelial cells and inflammatory cells, whereas IL\u20101\u03b2 and IL\u20101Ra were expressed only in inflammatory cells. Expression of the two IL\u20101 receptors and their ligands was significantly higher in patients than in controls. IL\u20101 receptor expression on muscle fibers was most pronounced in the vicinity of cells expressing IL\u20101\u03b1 and IL\u20101\u03b2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The increased expression of IL\u20101 receptor and the colocalization with reciprocal ligands in patients with myositis but not in healthy controls support the hypothesis of a crucial role of IL\u20101 in the pathogenesis of polymyositis and dermatomyositis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.22388","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T00:15:35Z","timestamp":1170461735000},"page":"674-687","source":"Crossref","is-referenced-by-count":55,"title":["Immunolocalization of interleukin\u20101 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies"],"prefix":"10.1002","volume":"56","author":[{"given":"Cecilia","family":"Grundtman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stina","family":"Salomonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Dorph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Bruton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid 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