{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:16Z","timestamp":1786977076941,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,30]],"date-time":"2007-01-30T00:00:00Z","timestamp":1170115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether vaccinations aggravate the course of autoimmune diseases such as juvenile idiopathic arthritis (JIA) and whether the immune response to vaccinations may be hampered by immunosuppressive therapy for the underlying disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this multicenter cohort study, 234 patients with JIA (ages 1\u201319 years) were vaccinated with meningococcal serogroup C (MenC) conjugate to protect against serogroup C disease (caused by\n                      <jats:italic>Neisseria meningitidis<\/jats:italic>\n                      ). Patients were followed up for disease activity for 1 year, from 6 months before until 6 months after vaccination. IgG antibody titers against MenC polysaccharide and the tetanus carrier protein were determined by enzyme\u2010linked immunosorbent assay and toxin binding inhibition assay, respectively. A serum bactericidal assay was performed to determine the function of the anti\u2010MenC antibodies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No change in values for any of the 6 components of the core set criteria for juvenile arthritis disease activity was seen after MenC vaccination. Moreover, no increase in the frequency of disease relapse was detected. Mean anti\u2010MenC IgG concentrations in JIA patients rose significantly within 6\u201312 weeks after vaccination. Of 157 patients tested, 153 were able to mount anti\u2010MenC IgG serum levels &gt;2 \u03bcg\/ml, including patients receiving highly immunosuppressive medication. The 4 patients with a lower anti\u2010MenC antibody response displayed sufficient bactericidal activity despite receiving highly immunosuppressive medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The MenC conjugate vaccine does not aggravate JIA disease activity or increase relapse frequency and results in adequate antibody levels, even in patients receiving highly immunosuppressive medication. Therefore, patients with JIA can be vaccinated safely and effectively with the MenC conjugate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.22399","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T19:08:49Z","timestamp":1170443329000},"page":"639-646","source":"Crossref","is-referenced-by-count":60,"title":["Safety and efficacy of meningococcal c vaccination in juvenile idiopathic arthritis"],"prefix":"10.1002","volume":"56","author":[{"given":"Evelien","family":"Zonneveld\u2010Huijssoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Ronaghy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion A. J.","family":"Van Rossum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ger T.","family":"Rijkers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona R. M.","family":"Van Der Klis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth A. M.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia E.","family":"Vermeer\u2010De Bondt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno W.","family":"Hoes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Jaap","family":"Van Der Net","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Engels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wietse","family":"Kuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berent J.","family":"Prakken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten J. D.","family":"Van Tol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico M.","family":"Wulffraat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,30]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14802-7"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2003.10.005"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.03.005"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102013440509"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102013440501"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102013440502"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.10.1694"},{"key":"e_1_2_7_9_2","first-page":"589","article-title":"Influenza vaccination in children with chronic rheumatic diseases and long\u2010term immunosuppressive therapy","volume":"19","author":"Kanakoudi\u2010Tsakalidou F","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_10_2","first-page":"1769","article-title":"Influenza immunization in children with chronic arthritis: a prospective study","volume":"20","author":"Malleson PN","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.013201"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.3.653"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.01.074"},{"key":"e_1_2_7_14_2","volume-title":"The Hague","author":"Inspectorate for Dutch Health Care","year":"2004"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10524"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.8.937"},{"key":"e_1_2_7_17_2","volume-title":"Vaccinations in the immunocompromised person: guidelines for the patient taking immunosuppressants, steroids and the new biologic therapies","author":"BSR Clinical Affairs Committee","year":"2002"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(99)90101-9"},{"key":"e_1_2_7_19_2","first-page":"932","article-title":"Universal vaccination against group C meningococci and pneumococci; advice from the Health Council of the Netherlands","volume":"146","author":"Van Furth AM","year":"2002","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_7_20_2","first-page":"85","article-title":"Causality assessment of adverse events following immunization","volume":"76","author":"World Health Organization","year":"2001","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.84.3.227"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6834.1075"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14072-X"},{"key":"e_1_2_7_24_2","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400703"},{"issue":"4","key":"e_1_2_7_26_2","first-page":"S1","article-title":"Cross\u2010cultural adaptation and psychometric evaluation of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ) in 32 countries: review of the general methodology","volume":"19","author":"Ruperto N","year":"2001","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"e_1_2_7_27_2","first-page":"S111","article-title":"The Dutch version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ)","volume":"19","author":"Wulffraat N","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_28_2","first-page":"393","article-title":"Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis","volume":"37","author":"Ritchie DM","year":"1968","journal-title":"Q J Med"},{"key":"e_1_2_7_29_2","first-page":"1058","article-title":"Preliminary definition of disease flare in juvenile rheumatoid arthritis","volume":"29","author":"Brunner HI","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_7_30_2","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1128\/jcm.32.6.1475-1482.1994","article-title":"Multicenter comparison of Neisseria meningitidis serogroup C anti\u2010capsular polysaccharide antibody levels measured by a standardized enzyme\u2010linked immunosorbent assay","volume":"32","author":"Gheesling LL","year":"1994","journal-title":"J Clin Microbiol"},{"key":"e_1_2_7_31_2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1128\/cdli.2.2.132-137.1995","article-title":"Assignment of Neisseria meningitidis serogroup A and C class\u2010specific anticapsular antibody concentrations to the new standard reference serum CDC1992","volume":"2","author":"Holder PK","year":"1995","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_7_32_2","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1128\/IAI.66.6.2453-2459.1998","article-title":"Age\u2010dependent Neisseria meningitidis serogroup C class\u2010specific antibody concentrations and bactericidal titers in sera from young children from Montana immunized with a licensed polysaccharide vaccine","volume":"66","author":"Maslanka SE","year":"1998","journal-title":"Infect Immun"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/140.5.690"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-1157(89)90009-7"},{"key":"e_1_2_7_35_2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1128\/cdli.4.2.156-167.1997","article-title":"Standardization and a multilaboratory comparison of Neisseria meningitidis serogroup A and C serum bactericidal assays","volume":"4","author":"Maslanka SE","year":"1997","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1568-1573.2001"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.6.1360"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70389-X"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/173.4.1009"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/154.6.1033"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-2607(96)01720-8"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200114235"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/2.6.880"},{"key":"e_1_2_7_44_2","first-page":"424","article-title":"Arthritis in children with bacterial meningitis","volume":"140","author":"Likitnukul S","year":"1986","journal-title":"Am J Dis Child"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80250-8"},{"key":"e_1_2_7_46_2","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1542\/peds.97.5.738","article-title":"Recurrent thrombocytopenic purpura after repeated measles\u2010mumps\u2010rubella vaccination","volume":"97","author":"Vlacha V","year":"1996","journal-title":"Pediatrics"},{"key":"e_1_2_7_47_2","first-page":"1203","article-title":"Immunization of patients with rheumatoid arthritis against influenza: a study of vaccine safety and immunogenicity","volume":"21","author":"Chalmers A","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.7.623"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812173392501"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030595"},{"key":"e_1_2_7_51_2","first-page":"1187","article-title":"Seasonal variation in systemic onset juvenile rheumatoid arthritis in Israel","volume":"26","author":"Uziel Y","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70115-4"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.9.4946-4954.2002"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1086\/317646"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00276-5"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei193"},{"key":"e_1_2_7_57_2","first-page":"1356","article-title":"Pneumococcal vaccine response in psoriatic arthritis patients during treatment with etanercept","volume":"31","author":"Mease PJ","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.98.2.196"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.451601"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.10.5.780-786.2003"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.22399","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.22399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T22:08:00Z","timestamp":1696975680000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.22399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,30]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1002\/art.22399"],"URL":"https:\/\/doi.org\/10.1002\/art.22399","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,30]]}}}