{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:27:12Z","timestamp":1791163632579,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T00:00:00Z","timestamp":1172620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2007,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There is evidence to support a dominant role for B cells in the pathophysiology of primary Sj\u00f6gren's syndrome (SS). Therefore, we evaluated the safety and efficacy of anti\u2010CD20 monoclonal antibody.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen patients who met the new American\u2010European Consensus Group criteria for primary SS and scored &gt;50 on at least 2 of 4 visual analog scales (VAS; 100 mm) evaluating global disease, pain, fatigue, and global dryness received infusions of low\u2010dose rituximab (375 mg\/m<jats:sup>2<\/jats:sup>) at weeks 0 and 1 without steroid premedication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Slow rituximab infusions (100 mg\/hour) were well tolerated, with only 1 patient experiencing serum sickness\u2013like disease. There was a dramatic reduction in B cells of the blood and salivary gland (SG). At week 12, VAS scores with respect to fatigue and dryness (<jats:italic>P<\/jats:italic> &lt; 0.05), tender point count (<jats:italic>P<\/jats:italic> &lt; 0.035), and quality of life as evaluated by the Short Form 36 questionnaire (SF\u201036; <jats:italic>P<\/jats:italic> &lt; 0.001) were significantly improved. At week 36, significant improvements were noted in the 4 VAS scores (<jats:italic>P<\/jats:italic> &lt; 0.05), tender joint count (<jats:italic>P<\/jats:italic> = 0.017), tender point count (<jats:italic>P<\/jats:italic> = 0.027), and SF\u201036 (<jats:italic>P<\/jats:italic> &lt; 0.03). Pulmonary manifestations were ameliorated in 1 patient. Patients with improvements on at least 3 of the 4 VAS scores at any visit (n = 11) had a shorter disease duration than the other patients (n = 5; mean \u00b1 SD duration 3.8 \u00b1 5.4 versus 30.1 \u00b1 29.5 years; <jats:italic>P<\/jats:italic> = 0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010dose rituximab infusions were well tolerated without the benefit of steroids. Infusions induced a rapid depletion of B cells in the blood and SG and could improve primary SS. Controlled studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.22536","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T23:20:19Z","timestamp":1172704819000},"page":"310-317","source":"Crossref","is-referenced-by-count":272,"title":["Improvement of Sj\u00f6gren's syndrome after two infusions of rituximab 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