{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:19:44Z","timestamp":1791429584786,"version":"4.3.3"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,3,29]],"date-time":"2007-03-29T00:00:00Z","timestamp":1175126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2007,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Individuals with medial compartment knee osteoarthritis (OA) and genu varum use different movement and muscle activation patterns to increase joint stability during gait. The purpose of this study was to ascertain whether opening\u2010wedge high\u2010tibial osteotomy (OW\u2010HTO) corrected pathomechancial abnormalities associated with the progression of knee OA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen patients diagnosed with medial knee OA and genu varum who were scheduled for OW\u2010HTO were tested prior to and 1 year following OW\u2010HTO. Fifteen age\u2010 and sex\u2010matched controls were also tested. Frontal plane laxity was measured from stress radiographs. All participants underwent quadriceps strength testing with a burst superimposition technique and gait analysis with surface electromyography to calculate knee joint kinematics and kinetics and muscle co\u2010contraction during the stance phase of gait. Participants rated their knee function and instability using a self\u2010report questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Static alignment improved following the surgery. Medial laxity (<jats:italic>P<\/jats:italic>= 0.003) and instability (<jats:italic>P<\/jats:italic>= 0.002) significantly improved, and statistical reductions in the adduction moment resulted in lower levels of vastus medialis\u2010medial gastrocnemius muscle co\u2010contractions (<jats:italic>P<\/jats:italic>= 0.089). Despite improvements in global rating of knee function (<jats:italic>P<\/jats:italic>= 0.001), the OA group's ratings remained significantly lower than those of the healthy controls (<jats:italic>P<\/jats:italic>= 0.001). Quadriceps strength deficits and knee flexion impairments persisted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Persistent quadriceps weakness and impaired knee kinematics after realignment suggest that the movement strategy may perpetuate joint destruction and impede the long\u2010term success of realignment. Rehabilitation should focus on quadriceps strength and improving joint mobility to improve the long\u2010term function of individuals with medial knee OA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.22608","type":"journal-article","created":{"date-parts":[[2007,3,29]],"date-time":"2007-03-29T18:54:32Z","timestamp":1175194472000},"page":"389-397","source":"Crossref","is-referenced-by-count":73,"title":["Effect of anatomic realignment on muscle function during gait in patients with medial compartment knee osteoarthritis"],"prefix":"10.1002","volume":"57","author":[{"given":"Dan 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