{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:25:45Z","timestamp":1791973545533,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,4,30]],"date-time":"2007-04-30T00:00:00Z","timestamp":1177891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2007,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The contribution of genetics to osteoarthritis (OA) progression is not known. To gain more insight into whether familial factors play a role in disease progression of OA, we analyzed familial aggregation of radiologic OA progression in a study of sibling pairs (the Genetics, Arthrosis, and Progression [GARP] study).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 105 white probands and their 105 siblings with OA at multiple joint sites were included in a prospective cohort study. Radiologic progression of OA was defined as a 1\u2010point score increase in total scores for severity of joint space narrowing (JSN) or osteophytes on standardized radiographs of the hands, knees, and hips obtained at baseline and after 2 years. Odds ratios were calculated for siblings and probands sharing radiologic disease progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 100 probands and 93 siblings were followed for 2 years (median age 60 years, 80% women). In 92 sibling pairs both the proband and sibling had complete radiographic followup. Radiologic progression of JSN and osteophytes was present in 47% and 42% of the probands and 34% and 37% of the siblings, respectively. The odds ratios (95% confidence intervals), adjusted for age, sex, and body mass index, of a sibling having radiologic progression if the proband had progression were 3.0 (1.2\u20137.8) for JSN progression and 1.5 (0.6\u20133.6) for osteophyte progression. A dose\u2010response relationship was found between the amount of increase in JSN total scores among probands and the progression of JSN in siblings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Familial factors played a role in the radiologic progression of JSN over 2 years in patients with OA at multiple sites.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.22680","type":"journal-article","created":{"date-parts":[[2007,4,30]],"date-time":"2007-04-30T18:17:06Z","timestamp":1177957026000},"page":"626-632","source":"Crossref","is-referenced-by-count":26,"title":["Influence of familial factors on radiologic disease progression over two years in siblings with osteoarthritis at multiple sites: A prospective longitudinal cohort study"],"prefix":"10.1002","volume":"57","author":[{"given":"Stella A.","family":"Botha\u2010Scheepers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Watt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"Slagboom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Meulenbelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits R.","family":"Rosendaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand C.","family":"Breedveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margreet","family":"Kloppenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,30]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:3<397::AID-ANR1>3.0.CO;2-X"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399405009257"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.024661"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290816"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340502"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780331101"},{"issue":"9","key":"e_1_2_8_8_2","first-page":"S361","article-title":"Nonfluoroscopic method for flexed radiography of the knee that allows reproducible joint space width measurement","volume":"41","author":"Peterfy CG","year":"1998","journal-title":"Arthritis Rheum"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-004-2312-6"},{"key":"e_1_2_8_10_2","first-page":"3","article-title":"Atlas of individual radiographic features in osteoarthritis","volume":"3","author":"Altman RD","year":"1995","journal-title":"Osteoarthritis Cartilage"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-194106000-00004"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.22.4.237"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20443"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024933620315"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20051"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110908"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119530"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200007)43:7<1456::AID-ANR7>3.0.CO;2-M"},{"key":"e_1_2_8_19_2","first-page":"1565","article-title":"Risk factors for progression to new sites of radiographically defined osteoarthritis in women","volume":"23","author":"Cerhan JR","year":"1996","journal-title":"J Rheumatol"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.22680","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.22680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T10:17:33Z","timestamp":1700043453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.22680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,30]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,5,15]]}},"alternative-id":["10.1002\/art.22680"],"URL":"https:\/\/doi.org\/10.1002\/art.22680","archive":["Portico"],"relation":{},"ISSN":["0893-7524","1529-0123"],"issn-type":[{"value":"0893-7524","type":"print"},{"value":"1529-0123","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,30]]}}}