{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:15:51Z","timestamp":1778915751213,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T00:00:00Z","timestamp":1180051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Ig molecules contain epitopes that can induce T cell\u2013mediated immune responses. B cells can process and present such epitopes and activate T cells. The purpose of the present study was to test our hypothesis that T cells that recognize an Ig consensus sequence presented by B cells will modulate lupus\u2010like disease in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>(NZB \u00d7 NZW)F<jats:sub>1<\/jats:sub> (NZB\/NZW) lupus mice received somatic B cell gene transfer of a DNA plasmid encoding a consensus sequence of T cell determinants of murine anti\u2010DNA IgG or control plasmids. Treated animals were monitored for the production of antibody, the development of renal disease, and the phenotype, number, and function of T cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment of mice with Ig consensus plasmid induced transforming growth factor \u03b2\u2013producing CD8+,CD28\u2013 T cells that suppressed the antigen\u2010specific stimulation of CD4+ T cells in a cell\u2010contact\u2013independent manner, reduced antibody production, retarded the development of nephritis, and improved survival. Significantly, adoptive transfer of CD8+,CD28\u2013 T cells from protected mice into hypergammaglobulinemic NZB\/NZW mice effectively protected the transferred mice from the development of renal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Gene expression of anti\u2010DNA Ig consensus sequence induces immunoregulatory T cells that delay the development of lupus nephritis by suppressing hypergammaglobulinemia and renal disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.22700","type":"journal-article","created":{"date-parts":[[2007,5,28]],"date-time":"2007-05-28T07:50:17Z","timestamp":1180338617000},"page":"1945-1953","source":"Crossref","is-referenced-by-count":21,"title":["Protection against renal disease in (NZB \u00d7 NZW)F<sub>1<\/sub> lupus\u2010prone mice after somatic B cell gene vaccination with anti\u2010DNA immunoglobulin consensus 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