{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:44:55Z","timestamp":1791297895662,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T00:00:00Z","timestamp":1185753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify susceptibility genes in a rat model of rheumatoid arthritis (RA) and to determine whether the corresponding human genes are associated with RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Genes influencing oil\u2010induced arthritis (OIA) were position mapped by comparing the susceptibility of inbred DA rats with that of DA rats carrying alleles derived from the arthritis\u2010resistant PVG strain in chromosomal fragments overlapping the quantitative trait locus <jats:italic>Oia2<\/jats:italic>. Sequencing of gene complementary DNA (cDNA) and analysis of gene messenger RNA (mRNA) expression were performed to attempt to clone a causal gene. Associations with human RA were evaluated by genotyping single\u2010nucleotide polymorphisms (SNPs) in the corresponding human genes and by analyzing frequencies of alleles and haplotypes in RA patients and age\u2010, sex\u2010, and area\u2010matched healthy control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Congenic DA rats were resistant to OIA when they carried PVG alleles for the antigen\u2010presenting lectin\u2010like receptor gene complex (<jats:italic>APLEC<\/jats:italic>), which encodes immunoregulatory C\u2010type lectin\u2013like receptors. Multiple differences in cDNA sequence and mRNA expression precluded cloning of a single causal gene. Five corresponding human <jats:italic>APLEC<\/jats:italic> genes were identified and targeted. The SNP rs1133104 in the dendritic cell immunoreceptor gene (<jats:italic>DCIR<\/jats:italic>), and a haplotype including that marker and 4 other SNPs in <jats:italic>DCIR<\/jats:italic> and its vicinity showed an indication of allelic association with susceptibility to RA in patients who were negative for antibodies to cyclic citrullinated peptide (anti\u2010CCP), with respective odds ratios of 1.27 (95% confidence interval [95% CI] 1.06\u20131.52; uncorrected <jats:italic>P<\/jats:italic> = 0.0073) and 1.37 (95% CI 1.12\u20131.67; uncorrected <jats:italic>P<\/jats:italic> = 0.0019). Results of permutation testing supported this association of the haplotype with RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rat <jats:italic>APLEC<\/jats:italic> is associated with susceptibility to polyarthritis, and human <jats:italic>APLEC<\/jats:italic> and <jats:italic>DCIR<\/jats:italic> may be associated with susceptibility to anti\u2010CCP\u2013negative RA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.22813","type":"journal-article","created":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T16:21:21Z","timestamp":1185812481000},"page":"2620-2632","source":"Crossref","is-referenced-by-count":91,"title":["Association of arthritis with a gene complex encoding C\u2010type lectin\u2013like receptors"],"prefix":"10.1002","volume":"56","author":[{"given":"Johnny C.","family":"Lorentzen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Flornes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Ekl\u00f6w","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liselotte","family":"B\u00e4ckdahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrica","family":"Ribbhammar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Ping","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Smolnikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Dissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Seddighzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Brookes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Alfredsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Klareskog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Padyukov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigbj\u00f6rn","family":"Fossum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,30]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/32.10.903"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1989.tb03185.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780301102"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(99)00052-4"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6383"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg224"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-004-0714-x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20316"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21575"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5319"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.5.2197"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/10.4.379"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.9.835"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.801103"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/5270"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.150201"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20066"},{"key":"e_1_2_8_20_2","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.2144\/02326mt03","article-title":"Creating arrays by centrifugation","volume":"32","author":"Jobs M","year":"2002","journal-title":"Biotechniques"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02498.x"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.10.1893"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65077-8"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.4.1973"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324230"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.9.5039"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200109)31:9<2733::AID-IMMU2733>3.0.CO;2-X"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2004.03.004"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1058"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2003.08.004"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104558"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1998.tb01185.x"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1055"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01633.x"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.12.1823"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304226200"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8411(03)00083-0"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1824"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065x.2001.1840117.x"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-8411(91)90050-M"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1999.00463.x"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199807)28:07<2188::AID-IMMU2188>3.0.CO;2-B"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.9979"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.18.10746"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1086\/319518"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20458"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10945"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.22813","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.22813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T14:51:58Z","timestamp":1698763918000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.22813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,30]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1002\/art.22813"],"URL":"https:\/\/doi.org\/10.1002\/art.22813","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,30]]}}}