{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:39:56Z","timestamp":1774366796462,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T00:00:00Z","timestamp":1185753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Recent evidence has highlighted a major genetic contribution to radiographic damage in rheumatoid arthritis (RA). The objective of this study was to determine whether genetic variants in the loci for interleukin\u20101 (IL\u20101), IL\u20106, IL\u201010, protein tyrosine phosphatase N22 (PTPN22), and selenoprotein S are associated with radiographic damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Modified Larsen scores of radiographic damage were determined in a cross\u2010sectional population of patients with RA (n = 964). Rheumatoid factor (RF) and anti\u2013cyclic citrullinated peptide (anti\u2010CCP) were also assayed. The Kruskal\u2010Wallis nonparametric test was used to compare median radiographic damage scores across genotype groups, followed by the Cuzick nonparametric test for trend to assess gene\u2010dose effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An allele\u2010dose association of IL\u20106 \u2212174G with increasing radiographic damage was present (<jats:italic>P<\/jats:italic> = 0.005), but only in patients who were RF positive (<jats:italic>P<\/jats:italic> = 0.004) or anti\u2010CCP positive (<jats:italic>P<\/jats:italic> = 0.01). Patients with the IL\u201010 \u2212592CC genotype had more extensive radiographic damage than did those with the AC or AA genotype (<jats:italic>P<\/jats:italic> = 0.006), but this was observed only among patients who were RF negative (<jats:italic>P<\/jats:italic> = 0.002) or anti\u2010CCP negative (<jats:italic>P<\/jats:italic> = 0.002). However, RF status and anti\u2010CCP status were not associated with the IL\u20106 or IL\u201010 genotype. No other genetic associations were detected, apart from a marginal association of PTPN22 +1858T with increased radiographic damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The reported associations of IL\u20106 \u2212174G with high IL\u20106 production and IL\u201010 \u2212592 with low IL\u201010 production and our own results support a role of genetically determined dysregulated cytokine production in disease severity. The lack of association of these genotypes with RF and anti\u2010CCP antibody status suggests that they act downstream of autoantibody production. We conclude that IL\u20106 and IL\u201010 genotypes may be useful in predicting disease severity in autoantibody\u2010positive and autoantibody\u2010negative patients, respectively.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.22814","type":"journal-article","created":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T16:19:29Z","timestamp":1185812369000},"page":"2549-2556","source":"Crossref","is-referenced-by-count":68,"title":["Association of interleukin\u20106 and interleukin\u201010 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status"],"prefix":"10.1002","volume":"56","author":[{"given":"I.","family":"Marinou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Healy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Mewar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. H.","family":"Binks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. S.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Walters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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