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RA subjects were defined as those who met \u22653 of 6 available 1987 American College of Rheumatology (ACR) criteria. Non\u2010RA subjects were defined as those who met no ACR criteria. We performed univariate and multivariate analyses of the association between RA and each novel and traditional CVD risk factor in RA versus non\u2010RA subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sample included 5,302 subjects ages \u226560, with 131 (2.5%) RA and 4,444 (84%) non\u2010RA participants. A total of 727 subjects were excluded. Plasma levels of antioxidants \u03b1\u2010carotene, \u03b2\u2010cryptoxanthin, lutein\/zeaxanthin, and lycopene were significantly lower in RA subjects compared with non\u2010RA subjects in multivariate analysis adjusting for potential confounders. Compared with non\u2010RA participants, RA subjects were more likely to have increased C\u2010reactive protein (CRP) levels in multivariate analysis adjusting for potential confounders. RA and non\u2010RA participants had similar prevalence of traditional CVD risk factors and previous CVD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this large population study, RA subjects had similar prevalence of previous CVD and traditional CVD risk factors as controls. Among novel CVD risk factors, plasma carotenoid levels were significantly lower and CRP level was significantly higher in RA compared with non\u2010RA subjects after adjustment for potential confounders. Further research should evaluate whether these differences account for the observed increased incidence of CVD in individuals with RA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.22912","type":"journal-article","created":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T16:48:57Z","timestamp":1185814137000},"page":"953-962","source":"Crossref","is-referenced-by-count":26,"title":["Antioxidants and other novel cardiovascular risk factors in subjects with rheumatoid arthritis in a large population sample"],"prefix":"10.1002","volume":"57","author":[{"given":"Paola","family":"De Pablo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth W.","family":"Karlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,30]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200112)44:12<2737::AID-ART460>3.0.CO;2-#"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000054612.26458.B2"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.018101"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.09.037"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.21.2124"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704033361401"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.2.237"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040967"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.634089"},{"key":"e_1_2_7_12_2","first-page":"875","article-title":"Activation of the immune system and inflammatory activity in relation to markers of atherothrombotic disease and atherosclerosis in rheumatoid arthritis","volume":"29","author":"Wallberg\u2010Jonsson S","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10089"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21397"},{"key":"e_1_2_7_15_2","first-page":"1219","article-title":"High\u2010grade C\u2010reactive protein elevation correlates with accelerated atherogenesis in patients with rheumatoid arthritis","volume":"32","author":"Gonzalez\u2010Gay MA","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.11.1065"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.15.1903"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601667"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.1.5"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000132197.67350.bd"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.6.1265"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7081.634"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00575-8"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1508"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605023341803"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/64.2.190"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.5.359"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.22.2674"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000106762.55994.86"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(02)02294-3"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.4.754"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118582"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(99)70260-X"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-105-5-649"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10343"},{"key":"e_1_2_7_36_2","first-page":"1","article-title":"Plan and operation of the Third National Health and Nutrition Survey, 1988\u20131994","volume":"32","author":"National Center for Health Statistics","year":"1994","journal-title":"Vital Health Stat"},{"key":"e_1_2_7_37_2","volume-title":"Third National Health and Nutrition Survey (NHANES III), 1988\u201394. 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