{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:53:50Z","timestamp":1790506430104,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T00:00:00Z","timestamp":1190937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2007,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the effect of a meditation training program, Mindfulness\u2010Based Stress Reduction (MBSR), on depressive symptoms, psychological status, and disease activity in patients with rheumatoid arthritis (RA) through a randomized, waitlist\u2010controlled pilot study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were randomized to either an MBSR group, where they attended an 8\u2010week course and 4\u2010month maintenance program, or to a waitlist control group, where they attended all assessment visits and received MBSR free of charge after study end. Participants received usual care from their rheumatologists throughout the trial. Self\u2010report questionnaires were used to evaluate depressive symptoms, psychological distress, well\u2010being, and mindfulness. Evaluation of RA disease activity (by Disease Activity Score in 28 joints) included examination by a physician masked to treatment status. Adjusted means and mean changes in outcomes were estimated in mixed model repeated measures analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010three participants were randomized: 31 to MBSR and 32 to control. At 2 months, there were no statistically significant differences between groups in any outcomes. At 6 months, there was significant improvement in psychological distress and well\u2010being (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.04 and\n                      <jats:italic>P<\/jats:italic>\n                      = 0.03, respectively), and marginally significant improvement in depressive symptoms and mindfulness (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.08 and\n                      <jats:italic>P<\/jats:italic>\n                      = 0.09, respectively). There was a 35% reduction in psychological distress among those treated. The intervention had no impact on RA disease activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An 8\u2010week MBSR class was not associated with change in depressive symptoms or other outcomes at 2\u2010month followup. Significant improvements in psychological distress and well\u2010being were observed following MBSR plus a 4\u2010month program of continued reinforcement. Mindfulness meditation may complement medical disease management by improving psychological distress and strengthening well\u2010being in patients with RA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.23010","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:24:32Z","timestamp":1191003872000},"page":"1134-1142","source":"Crossref","is-referenced-by-count":233,"title":["Effect of Mindfulness\u2010Based stress reduction in rheumatoid arthritis patients"],"prefix":"10.1002","volume":"57","author":[{"given":"Elizabeth 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