{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:07:12Z","timestamp":1791320832661,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,11,29]],"date-time":"2007-11-29T00:00:00Z","timestamp":1196294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2007,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate possible correlations between cutaneous polyarteritis nodosa (CPN) and antiphospholipid syndrome\u2013associated antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen patients were referred with CPN features. To investigate the possible role of antiphospholipid antibodies (aPL) in CPN, we measured serum lupus anticoagulant (LAC), IgG and IgM anticardiolipin (aCL) and anti\u2013phosphatidylserine\u2010prothrombin complex (anti\u2010PS\/PT) antibodies, and anti\u2013\u03b2<jats:sub>2<\/jats:sub>\u2010glycoprotein I\u2013dependent cardiolipin (anti\u2010\u03b2<jats:sub>2<\/jats:sub>GPI\/CL) antibodies in the 16 CPN patients, 8 microscopic polyangiitis (MPA) patients, 33 systemic lupus erythematosus (SLE) patients, and 23 healthy controls. LAC was determined according to the Subcommittee on Lupus Anticoagulant\/Phospholipid Dependent Antibody guidelines. Anti\u2010PS\/PT, aCL, and anti\u2010\u03b2<jats:sub>2<\/jats:sub>GPI\/CL antibodies were measured by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anti\u2010PS\/PT antibodies and\/or LAC were detected in all CPN patients, but not in any controls. Serum IgM anti\u2010PS\/PT antibody was found in 13 (81.3%) CPN patients. The mean \u00b1 SD serum anti\u2010PS\/PT IgM level (19.9 \u00b1 12.4 units\/ml) in CPN patients was significantly elevated compared with SLE patients (5.7 \u00b1 5.9 units\/ml). IgG anti\u2010PS\/PT antibody was detected in 5 (31.3%) CPN patients, but not in any controls. The IgG PS\/PT antibody titers were similar in CPN patients (12.3 \u00b1 12.0 units\/ml) and SLE patients (13.8 \u00b1 14.3 units\/ml). Three (18.8%) CPN patients were positive for IgG aCL antibody and 2 (12.5%) for IgM aCL antibody. No MPA patients had aPL. CPN skin manifestations included livedo reticularis (14 [87.5%]). Direct immunofluorescence (DIF) revealed C3 within the affected vessels in 7 (77.8%) of 9 CPN patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrated that presence of anti\u2010PS\/PT antibodies and\/or LAC could serve as markers in CPN patients. CPN could be dependently associated with the presence of anti\u2010PS\/PT antibody. Clinicians need to recognize these titers to permit early accurate diagnosis and treatment. We believe that anti\u2010PS\/PT antibodies will become widely recognized as a new factor when diagnosing CPN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.23081","type":"journal-article","created":{"date-parts":[[2007,11,29]],"date-time":"2007-11-29T16:46:58Z","timestamp":1196354818000},"page":"1507-1513","source":"Crossref","is-referenced-by-count":73,"title":["High titer of anti\u2013phosphatidylserine\u2010prothrombin complex antibodies in patients with cutaneous polyarteritis nodosa"],"prefix":"10.1002","volume":"57","author":[{"given":"Tamihiro","family":"Kawakami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahide","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Mizoguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinao","family":"Soma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1972.tb16181.x"},{"key":"e_1_2_6_3_2","first-page":"1308","article-title":"Necrotizing mesenteric vasculitis after longstanding cutaneous polyarteritis nodosa","volume":"19","author":"Dewar CL","year":"1992","journal-title":"J Rheumatol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1983.tb01744.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.02.018"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370206"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra002974"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199907)42:7<1309::AID-ANR1>3.0.CO;2-F"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/096120339600500519"},{"key":"e_1_2_6_11_2","first-page":"699","article-title":"The presence of anti\u2010phosphatidylserine\/prothrombin antibodies as risk factor for both arterial and venous thrombosis in patients with systemic lupus erythematosus","volume":"91","author":"Nojima J","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3334"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200009)43:9<1982::AID-ANR9>3.0.CO;2-2"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10831"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1649901"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00807.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5318.1571"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.6.3408"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.4049\/jimmunol.157.5.2201","article-title":"Anti\u2010phospholipid autoantibodies bind to apoptotic, but not viable, thymocytes in a beta 2\u2010glycoprotein I\u2010dependent manner","volume":"157","author":"Price BE","year":"1996","journal-title":"J Immunol"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1998.0235"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69114-9"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.020743"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.11.051"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01753.x"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.23081","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.23081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T16:00:54Z","timestamp":1696780854000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.23081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,29]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,12,15]]}},"alternative-id":["10.1002\/art.23081"],"URL":"https:\/\/doi.org\/10.1002\/art.23081","archive":["Portico"],"relation":{},"ISSN":["0893-7524","1529-0123"],"issn-type":[{"value":"0893-7524","type":"print"},{"value":"1529-0123","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,29]]}}}