{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:56:08Z","timestamp":1791006968438,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,11,29]],"date-time":"2007-11-29T00:00:00Z","timestamp":1196294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2007,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine an association between magnesium (Mg) depletion and chondrocalcinosis, which has been reported but not investigated in a cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prevalence of chondrocalcinosis was investigated in 144 individuals: 72 patients receiving home parenteral nutrition (HPN) compared with 72 age\u2010 and sex\u2010matched controls. Presence of chondrocalcinosis was assessed by knee radiographs. Blood serum and globular Mg levels and 24\u2010hour urinary Mg content were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean \u00b1 SD age for both patients and controls was 51 \u00b1 17 years, and 51% in both groups were women. Mean duration of HPN was 6.4 years. Prevalence of chondrocalcinosis was markedly higher in patients receiving HPN than controls (16.6% versus 2.7%; <jats:italic>P<\/jats:italic> = 0.006, odds ratio [OR] 7.0, 95% confidence interval [95% CI] 1.45\u201366.1). Mean \u00b1 SD serum and globular Mg levels were significantly lower in patients than controls (serum: 0.75 \u00b1 0.09 mmoles\/liter versus 0.81 \u00b1 0.08 mmoles\/liter, <jats:italic>P<\/jats:italic> = 0.0006; globular Mg: 1.8 \u00b1 0.31 mmoles\/liter versus 2.0 \u00b1 0.35 mmoles\/liter, <jats:italic>P<\/jats:italic> = 0.0003). Twenty\u2010four\u2010hour urinary Mg level was lower in patients than controls (mean \u00b1 SD 3.85 \u00b1 1.50 mmoles versus 5.37 \u00b1 3.71 mmoles; <jats:italic>P<\/jats:italic> = 0.001). Prevalence of chondrocalcinosis was significantly higher in patients with a low serum Mg level (OR 13.5, 95% CI 2.76\u2013127.3, <jats:italic>P<\/jats:italic> &lt; 0.0001), with a similarly high but not significant occurrence of chondrocalcinosis in patients with a low globular Mg level (OR 4.09, 95% CI 0.603\u201320.26, <jats:italic>P<\/jats:italic> = 0.08) and in patients with a low 24\u2010hour urinary Mg level (OR 3.9, 95% CI 0.77\u201316.34, <jats:italic>P<\/jats:italic> = 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Long\u2010lasting Mg depletion is strongly associated with chondrocalcinosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.23106","type":"journal-article","created":{"date-parts":[[2007,11,29]],"date-time":"2007-11-29T16:46:46Z","timestamp":1196354806000},"page":"1496-1501","source":"Crossref","is-referenced-by-count":53,"title":["Hypomagnesemia associated with chondrocalcinosis: A cross\u2010sectional 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