{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T07:59:57Z","timestamp":1778399997587,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,11,29]],"date-time":"2007-11-29T00:00:00Z","timestamp":1196294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the pattern of antibody responses to <jats:italic>Borrelia burgdorferi<\/jats:italic> in patients with antibiotic\u2010refractory, antibiotic\u2010responsive, or non\u2013antibiotic\u2010treated Lyme arthritis as an indirect measure of spirochetal persistence or eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>At least 3 serial serum samples from 41 patients with antibiotic\u2010refractory arthritis and 23 patients with antibiotic\u2010responsive arthritis, and samples from 10 non\u2013antibiotic\u2010treated, historical control patients were tested for IgG reactivity with <jats:italic>B burgdorferi<\/jats:italic> sonicate and 4 differentially expressed outer surface lipoproteins of the spirochete, by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among non\u2013antibiotic\u2010treated patients, antibody titers to <jats:italic>B burgdorferi<\/jats:italic> antigens remained high throughout a 2\u20135\u2010year period of arthritis. In contrast, in patients with antibiotic\u2010responsive arthritis, in whom joint swelling usually resolved during a 1\u2010month course of oral antibiotic therapy, the median antibody titers to most of the spirochetal antigens remained steady or decreased during the first 1\u20133 months after starting antibiotic therapy. In patients with antibiotic\u2010refractory arthritis, who had persistent joint swelling for a median duration of 10 months despite 2\u20133 months of oral or intravenous antibiotics, the median titers to most antigens increased slightly during the first 1\u20133 months. However, by 4\u20136 months after starting antibiotic therapy, reactivity with all antigens declined similarly in both antibiotic\u2010treated groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Whereas the antibody titers to <jats:italic>B burgdorferi<\/jats:italic> remained high in non\u2013antibiotic\u2010treated patients, the titers declined similarly 4\u20136 months after starting therapy in patients with antibiotic\u2010responsive or antibiotic\u2010refractory arthritis, suggesting that synovial inflammation persisted in patients with antibiotic\u2010refractory arthritis after the period of infection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.23135","type":"journal-article","created":{"date-parts":[[2007,11,29]],"date-time":"2007-11-29T17:18:22Z","timestamp":1196356702000},"page":"4216-4225","source":"Crossref","is-referenced-by-count":54,"title":["Antibody responses to <i>Borrelia burgdorferi<\/i> in patients with antibiotic\u2010refractory, antibiotic\u2010responsive, or non\u2013antibiotic\u2010treated lyme arthritis"],"prefix":"10.1002","volume":"56","author":[{"given":"Priya","family":"Kannian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"McHugh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara J. B.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rendi M.","family":"Bacon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa J.","family":"Glickstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen C.","family":"Steere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,29]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107123450207"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-5-725"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92011-9"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370616"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-005-0361-8"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22131"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007079705485"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1267"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199401273300401"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199912)42:12<2705::AID-ANR29>3.0.CO;2-H"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.2.392"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.1.173-181.1999"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/375371"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.5.2143-2153.1998"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.01103.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.12.3997-4004.1999"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.12.3990-3996.1999"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/374395"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80206-8"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.8.4196-4203.2002"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.4169-4173.2000"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.5.2951-2957.2005"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.7.2774-2779.1993"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2237407"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807233390401"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807233390402"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1086\/508667"},{"key":"e_1_2_7_29_2","first-page":"1","article-title":"Case definitions for public health surveillance","volume":"39","author":"Wharton M","year":"1990","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_7_30_2","first-page":"590","article-title":"Recommendations for test performance and interpretation from the Second National Conference on Serologic Diagnosis of Lyme Disease","volume":"44","year":"1995","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052471"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/149.5.789"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.6.2228-2235.1995"},{"key":"e_1_2_7_34_2","series-title":"The peptides: analysis, synthesis and biology","first-page":"1","author":"Barany G","year":"1980"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.1.382-388.2000"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.7.4003-4010.2003"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1086\/323392"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1086\/374376"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.23135","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.23135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T18:23:35Z","timestamp":1692555815000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.23135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,29]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1002\/art.23135"],"URL":"https:\/\/doi.org\/10.1002\/art.23135","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,29]]}}}