{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:21:01Z","timestamp":1791418861172,"version":"4.3.3"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,28]],"date-time":"2007-12-28T00:00:00Z","timestamp":1198800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare synovial tissue infiltrates from patients with anti\u2013cyclic citrullinated peptide (anti\u2010CCP)\u2013positive rheumatoid arthritis (RA) with those from patients with anti\u2010CCP\u2013negative RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Synovial tissue samples were obtained arthroscopically from the inflamed knee joints of 57 patients with RA (34 of whom were anti\u2010CCP positive) and examined for several histologic features along with immunohistologic expression of cell markers. Joint damage was assessed using the Kellgren\/Lawrence (K\/L) scale (range 0\u20134) on standard anteroposterior radiographs. In 31 patients (18 of whom were anti\u2010CCP positive), synovial tissue was available from an earlier time point, allowing analysis of temporal changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Synovial tissue from anti\u2010CCP\u2013positive patients was characterized by a higher mean number of infiltrating lymphocytes (61.6 versus 31.4\/high\u2010power field [hpf] [400\u00d7]; <jats:italic>P<\/jats:italic> = 0.01), less extensive fibrosis (mean score of 1.2 versus 2.0; <jats:italic>P<\/jats:italic> = 0.04), and a thinner synovial lining layer (mean score of 2.1 versus 3.3; <jats:italic>P =<\/jats:italic> 0.002) compared with synovial tissue from anti\u2010CCP\u2013negative patients. Anti\u2010CCP\u2013positive patients expressed more CD3, CD8, CD45RO, and CXCL12. More anti\u2010CCP\u2013positive patients had a K\/L score &gt;1 compared with anti\u2010CCP\u2013negative patients. The difference in the mean lymphocyte counts was already present a mean of 3.8 years before the index biopsy (76.7 lymphocytes\/hpf and 26.7 lymphocytes\/hpf in anti\u2010CCP\u2013positive patients and anti\u2010CCP\u2013negative patients, respectively; <jats:italic>P<\/jats:italic> = 0.008) and was independent of disease duration and K\/L score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Synovitis in patients with anti\u2010CCP\u2013positive RA differs from that in patients with anti\u2010CCP\u2013 negative RA, notably with respect to infiltrating lymphocytes, and is associated with a higher rate of local joint destruction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.23148","type":"journal-article","created":{"date-parts":[[2007,12,28]],"date-time":"2007-12-28T20:47:45Z","timestamp":1198874865000},"page":"53-60","source":"Crossref","is-referenced-by-count":121,"title":["Differences in synovial tissue infiltrates between anti\u2013cyclic citrullinated peptide\u2013positive rheumatoid arthritis and anti\u2013cyclic citrullinated peptide\u2013negative rheumatoid arthritis"],"prefix":"10.1002","volume":"58","author":[{"given":"M.","family":"van Oosterhout","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Bajema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. W. N.","family":"Levarht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. E. M.","family":"Toes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. W. J.","family":"Huizinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"van Laar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20044"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.041376"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20316"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.02.001"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1767"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22340"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199804)41:4<663::AID-ART13>3.0.CO;2-L"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar141"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199808)41:8<1481::AID-ART19>3.0.CO;2-O"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011565"},{"key":"e_1_2_6_15_2","first-page":"1311","article-title":"Tissue cytokine patterns distinguish variants of rheumatoid synovitis","volume":"151","author":"Klimiuk PA","year":"1997","journal-title":"Am J Pathol"},{"key":"e_1_2_6_16_2","first-page":"11","article-title":"Comparable histological appearance of synovitis in seropositive and seronegative rheumatoid arthritis","volume":"15","author":"Fujinami M","year":"1997","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20018"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.009225"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21373"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.5.472"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363975"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21302"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21385"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.23148","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.23148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:56:53Z","timestamp":1697039813000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.23148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,28]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1002\/art.23148"],"URL":"https:\/\/doi.org\/10.1002\/art.23148","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,28]]}}}