{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:21:14Z","timestamp":1759940474866},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,2,29]],"date-time":"2008-02-29T00:00:00Z","timestamp":1204243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether single\u2010nucleotide polymorphisms (SNPs) within the genes <jats:italic>PRF1, GZMB, UNC13D<\/jats:italic>, and <jats:italic>Rab27a,<\/jats:italic> which are involved in natural killer cell dysfunction and known to contribute to the risk of hemophagocytic lymphohistiocytosis (HLH), confer an increased risk of susceptibility to systemic\u2010onset juvenile idiopathic arthritis (JIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four SNPs across the <jats:italic>PRF1<\/jats:italic> gene locus, 5 for <jats:italic>GZMB<\/jats:italic>, 7 for <jats:italic>UNC13D<\/jats:italic>, and 11 for <jats:italic>Rab27a<\/jats:italic> were investigated using MassArray genotyping in 133 UK Caucasian patients with systemic\u2010onset JIA and 384 ethnically matched unrelated control subjects. Additional control genotypes were accessed from the data generated by the Wellcome Trust Case Control Consortium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant association was found between any SNP within the 4 selected loci and systemic\u2010onset JIA, by either single\u2010point or haplotype analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study demonstrate that genes involved in HLH do not confer a significant risk of association with systemic\u2010onset JIA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.23270","type":"journal-article","created":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:48:48Z","timestamp":1204332528000},"page":"869-874","source":"Crossref","is-referenced-by-count":26,"title":["Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic\u2010onset juvenile idiopathic arthritis"],"prefix":"10.1002","volume":"58","author":[{"given":"Rachelle","family":"Donn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Ellison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Lamb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Day","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Baildam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athimalaipet V.","family":"Ramanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,2,29]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3579(98)80018-6"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0889-857X(21)00134-4","article-title":"Juvenile rheumatoid arthritis: outcome and treatment for the 1990s","volume":"17","author":"Wallace CA","year":"1991","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh710"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20198"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.85.5.421"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.046904"},{"key":"e_1_2_7_8_2","first-page":"1133","article-title":"Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis","volume":"34","author":"Behrens EM","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_7_9_2","first-page":"121","article-title":"Is macrophage activation syndrome a new entity?","volume":"20","author":"Athreya BH","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000246626.57118.d9"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2003.110"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1453"},{"key":"e_1_2_7_13_2","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05911"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-072850"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj259"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.23270","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.23270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T02:40:14Z","timestamp":1698720014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.23270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,29]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1002\/art.23270"],"URL":"https:\/\/doi.org\/10.1002\/art.23270","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,29]]}}}