{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:26:29Z","timestamp":1790972789450,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,3,27]],"date-time":"2008-03-27T00:00:00Z","timestamp":1206576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Recent studies have shown that a nonsynonymous single\u2010nucleotide polymorphism (SNP) (Arg381Gln; rs11209026) in the interleukin\u201023 receptor (IL\u201023R) gene on chromosome 1p31 is associated with Crohn's disease and psoriasis. Given the clinical and immunologic overlap between ankylosing spondylitis (AS) and these diseases, and the potential function of this candidate SNP, this study was undertaken to examine the association of IL\u201023R variants with AS in multiple Canadian populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined 3 cohorts of AS patients from established rheumatic disease centers in Canada. The majority of AS patients were Caucasians of northern European descent, and all patients satisfied the modified New York classification criteria for AS or for juvenile spondylarthritis. We examined 424 AS probands and 401 controls from Alberta, 251 AS probands and 122 controls from Toronto, and 121 AS probands and 219 controls from Newfoundland. Ten IL\u201023R SNPs were genotyped, 9 of which were incorporated in the haplotype analysis. Allele and haplotype associations were calculated using the WHAP software package.<jats:italic>P<\/jats:italic>values for haplotype associations were calculated using a permutation test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The primary SNP of interest in a previous study of inflammatory bowel disease (IBD) (Arg381Gln; rs11209026) was found to be protective against AS in the Newfoundland population (<jats:italic>P<\/jats:italic>= 0.04) and in the Toronto population (<jats:italic>P<\/jats:italic>= 0.04) in single\u2010marker univariate analysis. The strongest association, however, was with SNP rs11465804 (<jats:italic>P<\/jats:italic>= 0.007 for the Newfoundland population and<jats:italic>P<\/jats:italic>= 0.0007 for the Toronto population). A 3\u2010marker sliding window omnibus test revealed a significant association with markers rs10489629, rs2201841, and rs11465804 in both the Newfoundland population (<jats:italic>P<\/jats:italic>= 0.04) and the Alberta population (<jats:italic>P<\/jats:italic>= 0.034). Our results were independent of the IBD and psoriasis status of the AS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This concurrent analysis of 3 distinct AS populations and their regional controls demonstrates a disease association with the IL\u201023R locus and implicates the same polymorphisms associated with IBD and psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.23389","type":"journal-article","created":{"date-parts":[[2008,3,28]],"date-time":"2008-03-28T02:17:08Z","timestamp":1206670628000},"page":"1020-1025","source":"Crossref","is-referenced-by-count":157,"title":["Association of interleukin\u201023 receptor variants with ankylosing spondylitis"],"prefix":"10.1002","volume":"58","author":[{"given":"Proton","family":"Rahman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Inman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafna D.","family":"Gladman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff P.","family":"Reeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette","family":"Peddle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter P.","family":"Maksymowych","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,3,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000231899.81677.04"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20308"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/424695"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11037"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel443"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135245"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/511051"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.1.7"},{"key":"e_1_2_6_10_2","first-page":"2667","article-title":"Inflammatory eye, skin, and bowel disease in spondyloarthritis: genetic, phenotypic, and environmental factors","volume":"28","author":"Brophy S","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22812"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_6_13_2","unstructured":"PurcellS ShamP. WHAP: SNP haplotype analysis package. URL:http:\/\/pngu.mgh.harvard.edu\/\u223cpurcell\/whap\/."},{"key":"e_1_2_6_14_2","unstructured":"ClaytonD. SNPHAP: a program for estimating frequencies of large haplotypes of SNPs. URL:http:\/\/www\u2010gene.cimr.cam.ac.uk\/clayton\/software\/."},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0107-26"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2007.00249.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215751"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207577200"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1648"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S1016-8478(23)13229-8","article-title":"Cytokine reporter mouse system for screening novel IL12\/23 p40\u2010inducing compounds","volume":"20","author":"Im W","year":"2005","journal-title":"Mol Cells"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05505"},{"key":"e_1_2_6_22_2","first-page":"S112","article-title":"IL\u201023R is a major determinant of ankylosing spondylitis risk\u2014the TASC study","volume":"66","author":"Reveille JD","year":"2007","journal-title":"Ann Rheum Disease"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/512133"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg257"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062382"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.23389","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.23389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T06:20:14Z","timestamp":1708755614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.23389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,27]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1002\/art.23389"],"URL":"https:\/\/doi.org\/10.1002\/art.23389","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,27]]}}}