{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:25:27Z","timestamp":1775892327986,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T00:00:00Z","timestamp":1209081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>T cell intracytoplasmic antigen 1 (TIA\u20101) and TIA\u20101\u2013related protein (TIAR) are involved in posttranscriptional regulation of the expression of tumor necrosis factor \u03b1 (TNF\u03b1) and other proteins. Given the pivotal role of TNF\u03b1 in chronic inflammatory diseases, this study was undertaken to analyze sera from patients with systemic autoimmune diseases for the presence of autoantibodies to TIA proteins and to investigate the expression of these proteins in inflamed tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The presence of autoantibodies to TIA proteins in sera from 385 patients with rheumatic diseases and healthy controls was determined by immunoblotting using recombinant antigens. Expression of TIA proteins in skin and kidney tissue was analyzed by immunohistochemistry. Serum levels of TNF\u03b1 were measured by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Autoantibodies to TIA\u20101 and\/or TIAR were detected in 61% of patients with systemic lupus erythematosus (SLE), 42% of patients with systemic sclerosis (SSc), 15\u201331% of patients with other rheumatic diseases, and 6% of healthy controls. Compared with patients negative for anti\u2010TIA antibody, anti\u2010TIA antibody\u2013positive SLE patients had higher disease activity (<jats:italic>P<\/jats:italic> = 0.01), elevated antibodies to double\u2010stranded DNA (<jats:italic>P<\/jats:italic> = 0.0003), and increased serum TNF\u03b1 levels (<jats:italic>P<\/jats:italic> = 0.018). In SLE patients, anti\u2010TIAR antibodies were associated with lupus nephritis (<jats:italic>P<\/jats:italic> = 0.02), while in patients with SSc, anti\u2013TIA\u20101 was associated with lung involvement (<jats:italic>P<\/jats:italic> = 0.02). Immunohistochemical analysis of skin and kidney tissue revealed aberrant expression of TIA proteins in skin lesions from SLE and SSc patients, as well as in glomerular cells from SLE patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aberrant expression of TIA proteins in inflammatory tissue may lead to systemic autoantibody responses, particularly in SLE and SSc. Increased occurrence of anti\u2010TIA autoantibodies in patients with severe organ involvement may point to a possible pathogenetic role.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.23435","type":"journal-article","created":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T20:47:17Z","timestamp":1209156437000},"page":"1226-1236","source":"Crossref","is-referenced-by-count":11,"title":["Autoantibodies to the translational suppressors T cell intracytoplasmic antigen 1 and T cell intracytoplasmic antigen 1\u2013related protein in patients with rheumatic diseases: Increased prevalence in systemic lupus erythematosus and systemic sclerosis and correlation with clinical 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