{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:36:55Z","timestamp":1790847415530,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T00:00:00Z","timestamp":1209081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the clinical response to interleukin\u20101 (IL\u20101) blockade and in vitro IL\u20101\u03b2 and IL\u201018 secretion in patients with systemic\u2010onset juvenile idiopathic arthritis (JIA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010two patients with systemic\u2010onset JIA were treated with the IL\u20101 receptor antagonist (IL\u20101Ra) anakinra. Monocytes from 18 patients and 20 healthy donors were activated by different Toll\u2010like receptor ligands. Intracellular and secreted IL\u20101\u03b2 and IL\u201018 were analyzed by Western blotting and enzyme\u2010linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten patients with systemic\u2010onset JIA exhibited a dramatic response to anakinra and were classified as complete responders. Eleven patients had an incomplete response or no response, and 1 patient could not be classified in terms of response. Compared with patients who had an incomplete response or no response, complete responders had a lower number of active joints (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02) and an increased absolute neutrophil count (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02). In vitro IL\u20101\u03b2 and IL\u201018 secretion in response to various stimuli was not increased and was independent of treatment efficacy. Likewise, secretion of IL\u20101Ra by monocytes from patients with systemic\u2010onset JIA was not impaired. An overall low level of IL\u20101\u03b2 secretion upon exposure to exogenous ATP was observed, unrelated to treatment responsiveness or disease activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Two subsets of systemic\u2010onset JIA can be identified according to patient response to IL\u20101 blockade. The 2 subsets appear to be characterized by some distinct clinical features. In vitro secretion of IL\u20101\u03b2 and IL\u201018 by monocytes from patients with systemic\u2010onset JIA is not increased and is independent of both treatment outcome and disease activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.23437","type":"journal-article","created":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T16:16:43Z","timestamp":1209140203000},"page":"1505-1515","source":"Crossref","is-referenced-by-count":325,"title":["The pattern of response to anti\u2013interleukin\u20101 treatment distinguishes two subsets of patients with systemic\u2010onset juvenile idiopathic 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