{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:04:51Z","timestamp":1773155091676,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T00:00:00Z","timestamp":1209081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Beh\u00e7et's syndrome is characterized by clusters of disease expression, one of which is the coexistence of acne and arthritis. The aim of this study was to test the hypothesis that enthesopathy is increased in this cluster, having features reminiscent of acne\u2010associated arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study group comprised 35 patients with Beh\u00e7et's syndrome who had acne and arthritis (BS\u2010AA), 38 patients with Beh\u00e7et's syndrome who did not have arthritis (BS\u2010WA), 37 patients with ankylosing spondylitis (AS), 25 patients with rheumatoid arthritis (RA), and 25 healthy control subjects. Five entheseal sites (the superior and inferior poles of the patella, the tibial tuberosity, and the superior and inferior poles of the calcaneus) on both lower extremities were examined by 2 independent observers, using ultrasonography. A previously validated composite score was calculated for each patient. The numbers of entheseal sites giving a positive power Doppler signal in each group were also compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with AS had the highest enthesopathy score (mean \u00b1 SD 4.1 \u00b1 2.4; F [4df] = 8.43, <jats:italic>P<\/jats:italic> &lt; 0.001) followed by BS\u2010AA patients (3.0 \u00b1 1.9; F [3df] = 3.63, <jats:italic>P<\/jats:italic> = 0.015). The mean \u00b1 SD enthesopathy scores among the remaining 3 groups were similar (for BS\u2010WA, 1.8 \u00b1 1.4; for RA, 2.2 \u00b1 1.6; for healthy controls, 2.0 \u00b1 1.5 [F (2df) = 0.65, <jats:italic>P<\/jats:italic> = 0.53]). Power Doppler scores were highest for the BS\u2010AA group (mean \u00b1 SD 3.0 \u00b1 1.5; F [4df] = 15.54, <jats:italic>P<\/jats:italic> &lt; 0.001) followed by the AS group (2.7 \u00b1 1.8; F [3df] = 14.38, <jats:italic>P<\/jats:italic> &lt; 0.001), the RA group (2.6 \u00b1 1.8; F [2df] = 13.88, <jats:italic>P<\/jats:italic> &lt; 0.001), the BS\u2010WA group (1.2 \u00b1 1.3; F [1df] = 4.48, <jats:italic>P<\/jats:italic> = 0.038), and the control group (0.5 \u00b1 1.1). There was 87% agreement between the 2 observers (\u03ba = 0.55, intraclass correlation coefficient 0.71).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The increased presence of enthesopathy among BS\u2010AA patients compared with that among BS\u2010WA patients further supports the hypothesis that patients with Beh\u00e7et's syndrome who also have arthritis and acne form a distinct cluster.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.23450","type":"journal-article","created":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T20:17:03Z","timestamp":1209154623000},"page":"1539-1545","source":"Crossref","is-referenced-by-count":96,"title":["Increased enthesopathy among Beh\u00e7et's syndrome patients with acne and arthritis: An ultrasonography study"],"prefix":"10.1002","volume":"58","author":[{"given":"Gulen","family":"Hatemi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izzet","family":"Fresko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koray","family":"Tascilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Yazici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,25]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"2393","article-title":"Target organ associations in Turkish patients with Behcet's disease: a cross sectional study by exploratory factor analysis","volume":"29","author":"Tunc R","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_3_2","first-page":"1078","article-title":"Criteria for diagnosis of Behcet's disease","volume":"335","author":"International Study Group for Behcet's Disease","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.10.905"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780040609"},{"key":"e_1_2_6_6_2","first-page":"684","article-title":"The clinical spectrum of the arthropathy associated with hidradenitis suppurativa and acne conglobata","volume":"20","author":"Rosner IA","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-4-520"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.162.2.2948214"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01582.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2006.05.001"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.11.1074"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.017467"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780391216"},{"key":"e_1_2_6_14_2","first-page":"281","volume-title":"Recent advances in Behcet's disease","author":"Dilsen N","year":"1986"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.40.6.558"},{"key":"e_1_2_6_16_2","first-page":"251","volume-title":"Beh\u00e7et's disease","author":"Hamza M","year":"1993"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-56-662-87"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2002.17.4.524"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009749709115831"},{"key":"e_1_2_6_20_2","first-page":"93","article-title":"Articular manifestations of Behcet's disease: apropos of 65 cases","volume":"54","author":"Imbert I","year":"1987","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.5.505"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2006.01.009"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10812"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.010314"},{"key":"e_1_2_6_25_2","first-page":"774","article-title":"Ultrasound detection of heel enthesitis: a comparison with magnetic resonance imaging","volume":"30","author":"Kamel M","year":"2003","journal-title":"J Rheumatol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.23450","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.23450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T23:30:20Z","timestamp":1698708620000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.23450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,25]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1002\/art.23450"],"URL":"https:\/\/doi.org\/10.1002\/art.23450","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,25]]}}}