{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:10:59Z","timestamp":1792080659518,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,5,31]],"date-time":"2008-05-31T00:00:00Z","timestamp":1212192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Progressive knee osteoarthritis (OA) is believed to result from local factors acting in a systemic environment. Previous studies have not examined these factors concomitantly or compared quantitative and qualitative cartilage loss outcomes. The aim of this study was to test whether meniscal damage, meniscal extrusion, malalignment, and laxity each predicted tibiofemoral cartilage loss after controlling for the other factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Laxity and alignment were measured at baseline in individuals with knee OA. Magnetic resonance imaging included spin\u2010echo coronal and sagittal imaging for meniscal scoring and axial and coronal spoiled gradient echo sequences with water excitation for cartilage quantification. Tibial and weight\u2010bearing femoral condylar subchondral bone area and cartilage surface were segmented. Cartilage volume, denuded bone area, and cartilage thickness were quantified in each plate, with progression defined as cartilage loss &gt;2 times the coefficient of variation for each plate. Qualitative outcome was assessed as worsening of the cartilage score. Logistic regression analysis with generalized estimating equations yielded odds ratios for each factor, adjusting for age, sex, body mass index, and the other factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We studied 251 knees in 153 persons. After full adjustment, medial meniscal damage predicted medial tibial cartilage volume loss and tibial and femoral denuded bone increase, while varus malalignment predicted medial tibial cartilage volume and thickness loss and tibial and femoral denuded bone increase. Lateral meniscal damage predicted every lateral outcome. Laxity and meniscal extrusion had inconsistent effects. After full adjustment, no factor except medial laxity predicted qualitative outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Using quantitative cartilage loss assessment, local factors that independently predicted tibial and femoral loss included medial meniscal damage and varus malalignment (medially) and lateral meniscal damage (laterally). A measurement of quantitative outcome was more sensitive at revealing these relationships than a qualitative approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.23462","type":"journal-article","created":{"date-parts":[[2008,5,31]],"date-time":"2008-05-31T17:17:08Z","timestamp":1212254228000},"page":"1716-1726","source":"Crossref","is-referenced-by-count":256,"title":["Relationship of meniscal damage, meniscal extrusion, malalignment, and joint laxity to subsequent cartilage loss in osteoarthritic knees"],"prefix":"10.1002","volume":"58","author":[{"given":"Leena","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Eckstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pottumarthi","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipali","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"September","family":"Cahue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hudelmaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Dunlop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,5,31]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"27","volume-title":"Osteoarthritis, diagnosis and medical\/surgical management","author":"Poole AR","year":"2007"},{"key":"e_1_2_6_3_2","first-page":"69","volume-title":"Osteoarthritis","author":"Brandt K","year":"2003"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198163040-00007"},{"key":"e_1_2_6_5_2","volume-title":"Biomechanics of the knee, with application to the pathogenesis and the surgical treatment of osteoarthritis","author":"Maquet PG","year":"1984"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67138-8"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(94)92194-6"},{"key":"e_1_2_6_8_2","first-page":"7","article-title":"Radiography and bone scintigraphy in osteoarthritis of the knee: comparison with MR imaging","volume":"418","author":"Boegard T","year":"1998","journal-title":"Acta Radiol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1999.0256"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200301000-00002"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0030-5898(20)31921-0","article-title":"Malalignment and degenerative arthropathy","volume":"25","author":"Tetsworth K","year":"1994","journal-title":"Orthop Clin North Am"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453679508995552"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.2.188"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00003086-199407000-00028","article-title":"Knee laxity in symptomatic osteoarthritis","volume":"304","author":"Brage ME","year":"1994","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.6.560"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199905)42:5<861::AID-ANR4>3.0.CO;2-N"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10573"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.023796"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21724"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_2_6_21_2","first-page":"1833","article-title":"Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee","volume":"15","author":"Bellamy N","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.11.003"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.039370"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21348"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21146"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1063"},{"key":"e_1_2_6_27_2","first-page":"71","article-title":"Protocols for precise radio\u2010anatomical positioning of the tibiofemoral and patellofemoral compartments of the knee","volume":"3","author":"Buckland\u2010Wright CB","year":"1995","journal-title":"Osteoarthritis Cartilage"},{"key":"e_1_2_6_28_2","volume-title":"Econometric analysis","author":"Greene WH","year":"1997"},{"key":"e_1_2_6_29_2","first-page":"31","volume-title":"Basic biomechanics of the musculoskeletal system","author":"Mow VC","year":"1989"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197658050-00003"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197506000-00027"},{"key":"e_1_2_6_32_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3928\/0147-7447-19920101-08","article-title":"The meniscus","volume":"15","author":"Bessette GC","year":"1992","journal-title":"Orthopedics"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198006000-00039"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11088"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(01)00081-X"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20379"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.7.617"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh017"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.62B3.7410467"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198365020-00016"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(70)90050-3"},{"key":"e_1_2_6_42_2","first-page":"185","volume-title":"Osteoarthritic disorders","author":"Woo SL","year":"1995"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000131639.89143.26"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200636050-00003"},{"key":"e_1_2_6_45_2","first-page":"107","volume-title":"The knee","author":"Solomonow M","year":"1994"},{"key":"e_1_2_6_46_2","first-page":"71","article-title":"The sensorimotor system, part I: the physiologic basis of functional joint stability","volume":"37","author":"Riemann BL","year":"2002","journal-title":"J Athl Train"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200309000-00021"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11483"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000144972.50849.d9"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.02.026"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.23462","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.23462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T11:04:53Z","timestamp":1697022293000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.23462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,31]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1002\/art.23462"],"URL":"https:\/\/doi.org\/10.1002\/art.23462","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,31]]}}}