{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:07:55Z","timestamp":1791295675843,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,5,31]],"date-time":"2008-05-31T00:00:00Z","timestamp":1212192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Wegener's granulomatosis (WG) and Churg\u2010Strauss syndrome (CSS) belong to the heterogeneous group of antineutrophil cytoplasmic antibody (ANCA)\u2013associated vasculitides. Current understanding of their pathogenesis and genetic background is limited. Expression levels of interleukin\u201010 (IL\u201010), a potent and pleiotropic cytokine, are largely determined by variations in the gene encoding the IL\u201010 precursor. This study was undertaken to determine the impact of <jats:italic>IL10<\/jats:italic> polymorphisms on the pathogenesis of both WG and CSS in large cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three single\u2010nucleotide polymorphisms (SNPs) tagging the promoter haplotypes of the <jats:italic>IL10<\/jats:italic> gene (<jats:italic>IL10<\/jats:italic> \u22123575, <jats:italic>IL10<\/jats:italic> \u22121082, and <jats:italic>IL10<\/jats:italic> \u2212592) were analyzed in 403 patients with WG and 103 patients with CSS as well as 507 matched control subjects from Germany. In addition, 3 informative SNPs in other parts of <jats:italic>IL10<\/jats:italic> were genotyped.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the markers or their haplotypes was associated with WG or any of its subgroups classified according to ANCA status, sex, or presence of further WG genetic risk factors. In contrast, the <jats:italic>IL10<\/jats:italic> \u22123575\/\u22121082\/\u2212592 TAC haplotype, part of the extended ancient haplotype IL10.2, was highly significantly associated with ANCA\u2010negative CSS (\u03c7<jats:sup>2<\/jats:sup> = 19.14, <jats:italic>P<\/jats:italic> = 0.000012, corrected <jats:italic>P<\/jats:italic> = 0.0003, odds ratio 2.16, 95% confidence interval 1.52\u20133.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings challenge those from previous studies of <jats:italic>IL10<\/jats:italic> in WG and provide further evidence that CSS and WG have distinct genetic backgrounds. Because the IL10.2 haplotype has been correlated reproducibly with increased <jats:italic>IL10<\/jats:italic> expression, the possible role of IL\u201010 in the pathogenesis of ANCA\u2010negative CSS needs to be further elucidated.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.23496","type":"journal-article","created":{"date-parts":[[2008,5,31]],"date-time":"2008-05-31T21:47:48Z","timestamp":1212270468000},"page":"1839-1848","source":"Crossref","is-referenced-by-count":101,"title":["Functionally relevant variations of the interleukin\u201010 gene associated with antineutrophil cytoplasmic antibody\u2013negative Churg\u2010Strauss syndrome, but not with Wegener's granulomatosis"],"prefix":"10.1002","volume":"58","author":[{"given":"S.","family":"Wieczorek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Hellmich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Arning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Moosig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Lamprecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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