{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:49:41Z","timestamp":1780472981182,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,6,24]],"date-time":"2008-06-24T00:00:00Z","timestamp":1214265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association of <jats:italic>NLRP3, NOD2, MEFV,<\/jats:italic> and <jats:italic>PSTPIP1<\/jats:italic>, genes that cause 4 of the autoinflammatory hereditary periodic fever syndromes (HPFS), with juvenile idiopathic arthritis (JIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010one single\u2010nucleotide polymorphisms (SNPs) across the 4 loci were investigated using MassArray genotyping in 950 Caucasian patients with JIA living in the UK and 728 ethnically matched healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prior to Bonferroni correction for multiple testing, significant genotype associations between 6 SNPs in <jats:italic>MEFV<\/jats:italic> and JIA were observed and, in subgroup analysis, associations between 12 SNPs across all 4 loci and the subgroup of patients with psoriatic JIA were found. After Bonferroni correction for multiple testing, 2 genotype associations remained significant in the subgroup of patients with psoriatic JIA (<jats:italic>MEFV<\/jats:italic> SNP rs224204 [corrected <jats:italic>P<\/jats:italic> = 0.025] and <jats:italic>NLRP3<\/jats:italic> SNP rs3806265 [corrected <jats:italic>P<\/jats:italic> = 0.04]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings support the use of monogenic loci as candidates for investigating the genetic component of complex disease and provide preliminary evidence of association between SNPs in autoinflammatory genes and psoriatic JIA. Our findings raise the interesting possibility of a shared disease mechanism between the HPFS and psoriatic JIA, potentially involving abnormal production of interleukin\u20101\u03b2.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.23604","type":"journal-article","created":{"date-parts":[[2008,6,24]],"date-time":"2008-06-24T13:04:08Z","timestamp":1214312648000},"page":"2142-2146","source":"Crossref","is-referenced-by-count":63,"title":["Autoinflammatory genes and susceptibility to psoriatic juvenile idiopathic arthritis"],"prefix":"10.1002","volume":"58","author":[{"given":"T. G.","family":"Day","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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P.","family":"Donn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,24]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"1991","article-title":"Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban","volume":"25","author":"Petty RE","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21392"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22444"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00504.2006"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061592"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05911"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2135380100"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/bor.0000174210.78449.6b"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.25.11874"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22305.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/35079114"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0351479"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/03009740600759639"},{"key":"e_1_2_7_15_2","first-page":"2014","article-title":"Mutations in the gene for familial Mediterranean fever: do they predispose to inflammation?","volume":"30","author":"Ozen S","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/94.10.527"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.23604","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.23604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T23:03:32Z","timestamp":1696979012000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.23604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,24]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1002\/art.23604"],"URL":"https:\/\/doi.org\/10.1002\/art.23604","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,24]]}}}