{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:48:19Z","timestamp":1772754499505,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T00:00:00Z","timestamp":1212105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate QuantiFERON\u2010tuberculosis Gold (QFT\u2010G) assay and tuberculin skin test (TST) for latent tuberculosis (TB) infection (LTBI) in patients with rheumatoid arthritis (RA) treated with adalimumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively followed up 43 RA patients who received adalimumab therapy and underwent serial TSTs and QFT\u2010G assays. TST was performed using Mantoux method and QFT\u2010G assay was examined by measuring interferon\u2010\u03b3 levels in whole blood samples that were incubated with early secretary antigenic target\u20106 and culture filtrate protein 10.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Before starting adalimumab therapy, 8 RA patients (18.6%) had positive and 35 (81.4%) had negative TST results. All 8 RA patients with positive TST results were diagnosed as LTBI and received isoniazid prophylaxis (INHP) 1 month before starting adalimumab therapy. None of these 8 RA patients developed active TB 2 years after completing INHP. A high rate (10 [37.0%] patients) of TST conversion was observed among 27 patients who had completed 12\u2010month adalimumab therapy. Of these 10 patients with TST conversion, 2 patients had positive QFT\u2010G results and 1 developed active TB disease. Among 17 RA patients who did not have TST conversion after 12\u2010month adalimumab therapy, 1 patient who had a positive QFT\u2010G result developed active TB disease. Of all 43 RA patients who received adalimumab therapy, 4 (9.3%) developed active TB after starting adalimumab therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The application of TST for detecting LTBI is limited in RA patients by the frequent presence of anergy. Combined QFT\u2010G assay and TST can aid in detecting LTBI in RA patients receiving adalimumab therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.23705","type":"journal-article","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T12:48:11Z","timestamp":1212151691000},"page":"800-806","source":"Crossref","is-referenced-by-count":87,"title":["Effectiveness of the combination of a whole\u2010blood interferon\u2010gamma assay and the tuberculin skin test in detecting latent tuberculosis infection in rheumatoid arthritis patients receiving adalimumab 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