{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:15:33Z","timestamp":1792512933532,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T00:00:00Z","timestamp":1212105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare measures of body fat and lean mass and the prevalence of abnormal body composition phenotypes (sarcopenia, overfat, and sarcopenic obesity) in men and women with rheumatoid arthritis (RA) versus matched controls, and to explore the disease\u2010related predictors of abnormal body composition in patients with RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 189 men and women with RA and 189 age\u2010, sex\u2010, and race\u2010matched non\u2010RA controls underwent dual\u2010energy x\u2010ray absorptiometry for measurement of total and regional body fat and lean mass. Continuous and categorical measures of body composition were compared between RA and control subjects by sex and according to categories of body mass index (BMI). Within the group of RA patients, demographic, lifestyle, and RA disease and treatment characteristics were compared for RA patients with healthy body composition versus those with abnormal body composition phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with non\u2010RA controls, RA status was significantly associated with greater odds of sarcopenia, overfat, and sarcopenic obesity in women, but not in men. Relative differences in body composition phenotypes between RA and control subjects were greatest for patients in the normal weight BMI category (&lt;25 kg\/m<jats:sup>2<\/jats:sup>). Among RA characteristics, increasing joint deformity, self\u2010reported disability scores, C\u2010reactive protein levels, rheumatoid factor seropositivity, and a lack of current treatment with disease\u2010modifying antirheumatic drugs were significantly associated with abnormal body composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Abnormal body composition phenotypes are overrepresented in patients with RA, particularly in those in the normal weight BMI range. RA\u2010associated disease and treatment characteristics contribute to this increase in abnormal body composition.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.23719","type":"journal-article","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T16:46:42Z","timestamp":1212166002000},"page":"807-815","source":"Crossref","is-referenced-by-count":203,"title":["Abnormal body composition phenotypes in older rheumatoid arthritis patients: Association with disease characteristics and pharmacotherapies"],"prefix":"10.1002","volume":"59","author":[{"given":"Jon T.","family":"Giles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari M.","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross E.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Towns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Fontaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M.","family":"Bathon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,5,30]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)69188-3"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117244"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.4.444"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.00540.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.250"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02051-X"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117936"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.107"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20878"},{"key":"e_1_2_7_11_2","first-page":"2475","article-title":"Comorbidity in arthritis","volume":"26","author":"Gabriel SE","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.279.2.E366"},{"key":"e_1_2_7_13_2","first-page":"23","article-title":"Tumor necrosis factor\u2010\u03b1 production is associated with less body cell mass in women with rheumatoid arthritis","volume":"31","author":"Walsmith J","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.56.5.326"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(01)00700-6"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.2.378"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh058"},{"key":"e_1_2_7_19_2","unstructured":"National Heart Lung and Blood Institute National Institutes of Health. 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