{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T03:21:35Z","timestamp":1780456895877,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T00:00:00Z","timestamp":1219968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The serum C\u2010reactive protein (CRP) concentration is commonly used in rheumatoid arthritis (RA) as a surrogate marker of systemic inflammation, presumably induced by synovitis. However, other tissues, such as adipose tissue, can induce CRP production. This study was undertaken to explore the associations between measures of adiposity and CRP levels in RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred ninety\u2010six men and women with RA underwent anthropometric assessment and total body dual\u2010energy x\u2010ray absorptiometry for measurement of total and regional body fat and lean mass. The associations between measures of fat and lean mass and serum levels of CRP and interleukin\u20106 (IL\u20106) were determined in analyses stratified by sex, with adjustment for pertinent demographic, lifestyle, and RA disease and treatment covariates as well as for the potential modifying effects of articular activity and biologic pharmacotherapeutic agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All measures of adiposity were significantly associated with the level of CRP in women, but not in men. In women, the measure of adiposity that showed the strongest association with the CRP level was truncal fat, in which, in adjusted analyses, each kilogram increase was associated with a 0.101\u2010unit increase in the logarithmically transformed CRP level (<jats:italic>P<\/jats:italic> &lt; 0.001). Neither the level of articular activity nor the use of biologic agents significantly modified this association in women. However, in men, elevated articular involvement was associated with a decreasing CRP level as truncal fat increased. For all analyses, substitution of IL\u20106 for CRP produced similar findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adiposity is independently associated with CRP levels in women with RA, and thus may confound the estimation of RA disease activity when serum CRP concentration is used as a surrogate for systemic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.23766","type":"journal-article","created":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T20:46:07Z","timestamp":1220042767000},"page":"2632-2641","source":"Crossref","is-referenced-by-count":65,"title":["Association of body fat with C\u2010reactive protein in rheumatoid arthritis"],"prefix":"10.1002","volume":"58","author":[{"given":"Jon T.","family":"Giles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Fontaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M.","family":"Bathon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,29]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360601"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_7_4_2","first-page":"623","article-title":"Testing of the preliminary OMERACT validation criteria for a biomarker to be regarded as reflecting structural damage endpoints in rheumatoid arthritis clinical trials: the example of C\u2010reactive protein","volume":"34","author":"Keeling SO","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400607"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200105)44:5<997::AID-ANR178>3.0.CO;2-C"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000130640.77501.79"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.02.051"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.1.31"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11127"},{"key":"e_1_2_7_12_2","first-page":"1480","article-title":"The clinical value of the Stanford Health Assessment Questionnaire Functional Disability Index in patients with rheumatoid arthritis","volume":"15","author":"Wolfe F","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114163"},{"key":"e_1_2_7_14_2","volume-title":"Physical activity and health: a report of the Surgeon General","author":"US Department of Health and Human Services","year":"1996"},{"key":"e_1_2_7_15_2","first-page":"681","article-title":"Independent role of conventional cardiovascular risk factors as predictors of C\u2010reactive protein concentrations in rheumatoid arthritis","volume":"34","author":"Dessein PH","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel149"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.056937"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-06-0737"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.6.7580"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000088261"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.8.902"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20407"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2004.06.013"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117244"},{"key":"e_1_2_7_25_2","first-page":"23","article-title":"Tumor necrosis factor\u2010\u03b1 production is associated with less body cell mass in women with rheumatoid arthritis","volume":"31","author":"Walsmith J","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.56.5.326"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802695"}],"container-title":["Arthritis &amp; 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