{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:55:52Z","timestamp":1791255352780,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T00:00:00Z","timestamp":1219968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[2008,9]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n The\n STAT4<\/jats:italic>\n gene encodes a transcription factor involved in the signaling pathways of several cytokines, including interleukin\u201012 (IL\u201012), the type I interferons, and IL\u201023. Recently, the association of a\n STAT4<\/jats:italic>\n haplotype marked by rs7574865 with rheumatoid arthritis (RA) and systemic lupus erythematosus was reported. The aim of this study was to investigate the role of this\n STAT4<\/jats:italic>\n tagging polymorphism in other immune\u2010mediated diseases.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The study group comprised 2,776 consecutively recruited Spanish individuals: 575 with RA, 440 with multiple sclerosis, 700 with inflammatory bowel disease, 311 with type 1 diabetes, and 723 ethnically matched healthy control subjects. The\n STAT4<\/jats:italic>\n polymorphism rs7574865 was genotyped using a predesigned TaqMan assay. Allele and genotype frequencies in patients and control subjects were compared by chi\u2010square test.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The association of\n STAT4<\/jats:italic>\n polymorphism rs7574865 with RA was validated in patients of Spanish origin (for T versus G,\n P<\/jats:italic>\n = 1.2 \u00d7 10\n \u22126<\/jats:sup>\n , odds ratio [OR] 1.59, 95% confidence interval [95% CI] 1.31\u20131.92), and the association was described for the first time in both clinical forms of inflammatory bowel disease, Crohn's disease and ulcerative colitis (for T versus G,\n P<\/jats:italic>\n = 0.006, OR 1.29, 95% CI 1.07\u20131.55), and in type 1 diabetes mellitus (for T versus G,\n P<\/jats:italic>\n = 0.008, OR 1.36, 95% CI 1.07\u20131.71). In contrast, the genotypic distribution of this polymorphism showed no difference between patients with multiple sclerosis and healthy control subjects (for T versus G,\n P<\/jats:italic>\n = 0.83, OR 1.02, 95% CI 0.82\u20131.28).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The\n STAT4<\/jats:italic>\n gene is emerging as a novel common risk factor for diverse complex diseases.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.23792","type":"journal-article","created":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T16:46:07Z","timestamp":1220028367000},"page":"2598-2602","source":"Crossref","is-referenced-by-count":108,"title":["Association of the STAT4 gene with increased susceptibility for some immune\u2010mediated diseases"],"prefix":"10.1002","volume":"58","author":[{"given":"A.","family":"Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Varad\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"M\u00e1rquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"C\u00e9nit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Espino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Perdigones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Santiago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fern\u00e1ndez\u2010Arquero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"de la Calle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Arroyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Fern\u00e1ndez\u2010Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. G.","family":"de la Concha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Urcelay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,29]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073003"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364295"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.2119\/2007-00072.Lee"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.81"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.8.4901"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.10.003"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1375.024"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1385\/IR:31:3:231"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130302"},{"key":"e_1_2_7_12_2","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.2337\/diacare.29.s1.06.s43","article-title":"Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","volume":"29","author":"American Diabetes Association","year":"2006","journal-title":"Diabetes Care"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05911"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.060822"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207999200"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40615.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/135245859900500206"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0502-500"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0907-1053"}],"container-title":["Arthritis & Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.23792","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.23792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T19:22:21Z","timestamp":1696965741000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.23792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,29]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1002\/art.23792"],"URL":"https:\/\/doi.org\/10.1002\/art.23792","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1123996.581106","asserted-by":"object"}]},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,29]]}}}