{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:14:18Z","timestamp":1770412458055,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,9,29]],"date-time":"2008-09-29T00:00:00Z","timestamp":1222646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether percent true calcium absorption (\u03b1) is normal and whether supplementation with placebo, vitamin D<jats:sub>3<\/jats:sub> (2,000 IU\/day), calcium (1,000 mg\/day), or vitamin D<jats:sub>3<\/jats:sub> plus calcium improves \u03b1, mineral metabolism, or bone mass accrual in children with arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen children received all 4 treatments, each for 6 months, in 4 different, randomly assigned orders. Changes in levels of 25\u2010hydroxyvitamin D (25[OH]D), 1,25\u2010dihydroxyvitamin D (1,25[OH]<jats:sub>2<\/jats:sub>D), parathyroid hormone, bone turnover markers, and minerals and in bone mineral content were measured. Calcium absorption was determined with a dual stable isotope method using <jats:sup>48<\/jats:sup>Ca administered intravenously and <jats:sup>46<\/jats:sup>Ca administered orally, and measuring <jats:sup>48<\/jats:sup>Ca, <jats:sup>46<\/jats:sup>Ca, and <jats:sup>42<\/jats:sup>Ca in a 24\u2010hour urine specimen by high\u2010resolution inductively coupled plasma mass spectroscopy. Wilcoxon's signed rank test was used both to identify significant change over the treatment period with a given regimen and to compare change with an experimental treatment versus change with placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Percent true calcium absorption was in the lower\u2010normal range and did not differ by treatment (mean \u00b1 SD 28.3 \u00b1 20.2% with placebo, 26.1 \u00b1 12.1% with calcium, 19.2 \u00b1 11.7% with vitamin D<jats:sub>3<\/jats:sub>, and 27.1 \u00b1 16.5% with vitamin D<jats:sub>3<\/jats:sub> plus calcium). With vitamin D<jats:sub>3<\/jats:sub> and vitamin D<jats:sub>3<\/jats:sub> plus calcium treatment, 25(OH)D levels were increased and 1,25(OH)<jats:sub>2<\/jats:sub>D levels were maintained. Serum calcium levels were increased only with vitamin D<jats:sub>3<\/jats:sub> and vitamin D<jats:sub>3<\/jats:sub> plus calcium treatment. Levels of bone turnover markers and increases in bone mineral content did not differ by treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings of this study indicate that percent true calcium absorption is low\u2010normal in children with arthritis. Vitamin D<jats:sub>3<\/jats:sub> at 2,000 IU\/day increases serum 25(OH)D and calcium levels but does not improve bone mass accretion. Calcium at 1,000 mg\/day also failed to improve bone mass.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.23809","type":"journal-article","created":{"date-parts":[[2008,9,29]],"date-time":"2008-09-29T04:33:23Z","timestamp":1222662803000},"page":"3255-3263","source":"Crossref","is-referenced-by-count":21,"title":["Percent true calcium absorption, mineral metabolism, and bone mass in children with arthritis: Effect of supplementation with vitamin D<sub>3<\/sub> and calcium"],"prefix":"10.1002","volume":"58","author":[{"given":"Laura S.","family":"Hillman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James T.","family":"Cassidy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fungai","family":"Chanetsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John 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