{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:01:56Z","timestamp":1790233316093,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,7,30]],"date-time":"2008-07-30T00:00:00Z","timestamp":1217376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the modulation of systemic levels of soluble interleukin\u20106 receptor (sIL\u20106R) and soluble gp130 (sgp130) in untreated and treated polymyalgia rheumatica (PMR) patients during a followup period of at least 24 months in order to evaluate the relationship of these molecules with clinical outcome and their feasibility to provide a prognostic tool in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed sIL\u20106R and sgp130 serum levels in 93 PMR patients, and 46 age\u2010matched normal controls, at disease onset and at 1, 3, 6, 12, and 24 months of followup during corticosteroid therapy by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No difference in sIL\u20106R and sgp130 levels was observed between PMR patients and normal controls at disease onset or during followup. A significant correlation was found between the number of relapses and sIL\u20106R concentrations at baseline and after 1, 3, and 12 months of therapy. No correlation was found between sgp130 levels and the number of relapses. Cox multivariate analysis indicated that the best model for predicting relapses was identified by sIL\u20106R levels and the hemoglobin value at baseline. We found that high sIL\u20106R levels combined with low hemoglobin values resulted in a 10.1\u2010fold increased risk of relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data support the identification of a potential prognostic marker of PMR outcome that might have important implications in clinical practice. Because targeting sIL\u20106R with blocking antibodies has proven useful in other rheumatic disorders, our results could suggest the opportunity to evaluate sIL\u20106R\u2013blocking treatment in patients with PMR and elevated levels of sIL\u20106R at disease onset.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.23924","type":"journal-article","created":{"date-parts":[[2008,8,2]],"date-time":"2008-08-02T04:58:31Z","timestamp":1217653111000},"page":"1147-1154","source":"Crossref","is-referenced-by-count":31,"title":["Serum interleukin\u20106 receptor in polymyalgia rheumatica: A potential marker of relapse\/recurrence 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