{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:26:53Z","timestamp":1783124813493,"version":"3.54.6"},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T00:00:00Z","timestamp":1219968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify characteristics that predict a valid rheumatoid arthritis (RA) or juvenile idiopathic arthritis (JIA) diagnosis among RA\u2010 and JIA\u2010coded individuals in the General Practice Research Database (GPRD), and to assess limitations of this type of diagnostic validation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four RA and 2 JIA diagnostic groups were created with differing strengths of evidence of RA\/JIA (Group 1 = strongest evidence), based on RA\/JIA medical codes. Individuals were sampled from each group and clinical and prescription data were extracted from anonymized hospital\/practice correspondence and electronic records. American College of Rheumatology and International League of Associations for Rheumatology diagnostic criteria were used to validate diagnoses. A data\u2010derived diagnostic algorithm that maximized sensitivity and specificity was identified using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 223 RA\u2010coded individuals, the diagnostic algorithm classified individuals as having RA if they had an appropriate GPRD disease\u2010modifying antirheumatic drug prescription or 3 other GPRD characteristics: &gt;1 RA code during followup, RA diagnostic Group 1 or 2, and no later alternative diagnostic code. This algorithm had &gt;80% sensitivity and specificity when applied to a test data set. Among 101 JIA\u2010coded individuals, the strongest predictor of a valid diagnosis was a Group 1 diagnostic code (&gt;90% sensitivity and specificity).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Validity of an RA diagnosis among RA\u2010coded GPRD individuals appears high for patients with specific characteristics. The findings are important for both interpreting results of published GPRD studies and identifying RA\/JIA patients for future GPRD\u2010based research. However, several limitations were identified, and further debate is needed on how best to validate chronic disease diagnoses in the GPRD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.24015","type":"journal-article","created":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T21:03:01Z","timestamp":1220043781000},"page":"1314-1321","source":"Crossref","is-referenced-by-count":122,"title":["How accurate are diagnoses for rheumatoid arthritis and juvenile idiopathic arthritis in the general practice research database?"],"prefix":"10.1002","volume":"59","author":[{"given":"S. L.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Smeeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,29]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Key health statistics from general practice 1996: series MB6 No1","author":"Office for National Statistics","year":"1998"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)04248-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei024"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.10.1105"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22683"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.024091"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.6.676"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22294"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.048835"},{"key":"e_1_2_6_11_2","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_13_2","first-page":"1420","article-title":"A comparison of the performance of different methods of disease classification for rheumatoid arthritis: results of an analysis from a nationwide twin study","volume":"21","author":"MacGregor AJ","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.6.1081"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.24015","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.24015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T21:17:41Z","timestamp":1696972661000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.24015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,29]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9,15]]}},"alternative-id":["10.1002\/art.24015"],"URL":"https:\/\/doi.org\/10.1002\/art.24015","archive":["Portico"],"relation":{},"ISSN":["0893-7524","1529-0123"],"issn-type":[{"value":"0893-7524","type":"print"},{"value":"1529-0123","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,29]]}}}