{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:28:15Z","timestamp":1791300495667,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study tumor necrosis factor \u03b1 (TNF\u03b1) and interleukin\u20101 (IL\u20101) cytokine polymorphisms as possible risk and protective factors, define their relative importance, and examine these as severity factors in patients with juvenile dermatomyositis (DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>TNF\u03b1 and IL\u20101 cytokine polymorphism and HLA typing were performed in 221 Caucasian patients with juvenile DM, and the results were compared with those in 203 ethnically matched healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The genotypes TNF\u03b1 \u2212308AG (odds ratio [OR] 3.6), TNF\u03b1 \u2212238GG (OR 3.5), and IL\u20101\u03b1 +4845TT (OR 2.2) were risk factors, and TNF\u03b1 \u2212308GG (OR 0.26) as well as TNF\u03b1 \u2212238AG (OR 0.22) were protective, for the development of juvenile DM. Carriage of a single copy of the TNF\u03b1 \u2212308A (OR 3.8) or IL\u20101\u03b2 +3953T (OR 1.7) allele was a risk factor, and the TNF\u03b1 \u2212238A (OR 0.29) and IL\u20101\u03b1 +4845G (OR 0.46) alleles were protective, for juvenile DM. Random Forests classification analysis showed HLA\u2013DRB1*03 and TNF\u03b1 \u2212308A to have the highest relative importance as risk factors for juvenile DM compared with the other alleles (Gini scores 100% and 90.7%, respectively). TNF\u03b1 \u2212308AA (OR 7.3) was a risk factor, and carriage of the TNF\u03b1 \u2212308G (OR 0.14) and IL\u20101\u03b1 \u2212889T (OR 0.41) alleles was protective, for the development of calcinosis. TNF\u03b1 \u2212308AA (OR 7.0) was a possible risk factor, and carriage of the TNF\u03b1 \u2212308G allele (OR 0.14) was protective, for the development of ulcerations. None of the studied TNF\u03b1, IL\u20101\u03b1, and IL\u20101\u03b2 polymorphisms were associated with the disease course, disease severity at the time of diagnosis, or the patient's sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TNF\u03b1 and IL\u20101 genetic polymorphisms contribute to the development of juvenile DM and may also be indicators of disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.24039","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T11:46:59Z","timestamp":1227959219000},"page":"3941-3950","source":"Crossref","is-referenced-by-count":78,"title":["Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis"],"prefix":"10.1002","volume":"58","author":[{"given":"Gulnara","family":"Mamyrova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrance 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