{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:19:23Z","timestamp":1770412763585,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effects of calcium supplementation on bone physiology in corticosteroid\u2010free children with juvenile rheumatoid arthritis (JRA) by measuring serum and urinary bone\u2010related hormones, minerals, and markers of bone formation and resorption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this double\u2010blind trial, patients were randomized to receive daily oral supplementation with 1,000 mg of calcium and 400 IU of vitamin D or with placebo and 400 IU of vitamin D for 24 months. The effect of calcium supplementation on bone physiology was determined periodically using markers of bone turnover.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred ninety\u2010eight patients met the inclusion criteria and were followed up in the study. At baseline, there were no differences in markers of bone turnover between the groups. Patients with \u22644 joints with active disease had higher serum levels of calcium and parathyroid hormone (PTH). Calcium\u2010treated patients with \u22644 joints with active disease had lower levels of osteocalcin (OC). At followup, levels of 1,25\u2010dihydroxyvitamin D<jats:sub>3<\/jats:sub>, PTH, OC, and urine phosphorus were lower in the group receiving calcium supplementation. Hypercalciuria, as determined by the urinary calcium\u2010to\u2010creatinine ratio, was not noted in 24\u2010hour urine studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Levels of markers of bone physiology were significantly decreased in children with JRA receiving calcium supplementation. The physiologic changes were noted as early as 12 months into calcium supplementation. The hypercalciuria noted on spot testing of the urinary calcium\u2010to\u2010creatinine ratio was not demonstrated on further evaluation, nor did it lead to renal pathology. These findings suggest that the calcium supplementation met physiologic needs and caused an increased calcium loss in urine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.24041","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T11:46:59Z","timestamp":1227959219000},"page":"3932-3940","source":"Crossref","is-referenced-by-count":18,"title":["Biochemical markers of bone turnover associated with calcium supplementation in children with juvenile rheumatoid arthritis: Results of a double\u2010blind, placebo\u2010controlled intervention trial"],"prefix":"10.1002","volume":"58","author":[{"given":"Ruy","family":"Carrasco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Lovell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward 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