{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:38:51Z","timestamp":1793644731613,"version":"4.5.1"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To use a combination of magnetic resonance diffusion\u2010tensor imaging (MR\u2010DTI) and MR imaging of voxel\u2010based morphometry (MR\u2010VBM) in patients with fibromyalgia syndrome (FMS) to determine microstructural and volume changes in the central neuronal networks involved in the sensory\u2010discriminative and affective\u2010motivational characteristics of pain, anxiety, memory, and regulation of the stress response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty female patients with FMS and 30 healthy female control subjects were studied. Predefined areas of the brain were measured for volume of gray matter by MR\u2010VBM and for diffusivity and fractional anisotropy (FA) by MR\u2010DTI. Higher FA values and reduced diffusivity are thought to reflect increased complexity of brain\u2010tissue microstructure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MR\u2010VBM and MR\u2010DTI demonstrated a striking pattern of changes in brain morphology in patients with FMS. Both thalami, the thalamocortical tracts, and both insular regions showed significant decreases in FA. In contrast, increases in FA and decreases in gray matter volume were seen in the postcentral gyri, amygdalae, hippocampi, superior frontal gyri, and anterior cingulate gyri. Increased pain intensity scores were correlated with changes in MR\u2010DTI measurements in the right superior frontal gyrus. Increased fatigue was correlated with changes in the left superior frontal and left anterior cingulate gyrus, and self\u2010perceived physical impairment was correlated with changes in the left postcentral gyrus. Higher intensity scores for stress symptoms were correlated negatively with diffusivity in the thalamus and FA in the left insular cortex. No relationship was found between MR\u2010VBM measurements and symptom intensity scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MR\u2010DTI allows the visualization of microstructural changes in the brain of patients with FMS, appears to be more sensitive than MR\u2010VBM, and may serve as an additional diagnostic technique in FMS and probably other dysfunctional pain syndromes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.24070","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T11:46:59Z","timestamp":1227959219000},"page":"3960-3969","source":"Crossref","is-referenced-by-count":245,"title":["White and gray matter abnormalities in the brain of patients with fibromyalgia: A diffusion\u2010tensor and volumetric imaging study"],"prefix":"10.1002","volume":"58","author":[{"given":"J\u00fcrgen","family":"Lutz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"de Quervain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Krauseneck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Padberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Wichnalek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Beyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Zirngibl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Morhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Reiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustav","family":"Schelling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,11,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-10-200705150-00006"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2094"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-003-1114-x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1996.0086"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20102"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rhu.0000221817.46231.18"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2004.04003.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330203"},{"key":"e_1_2_6_10_2","first-page":"1984","article-title":"Validation of a German version of the Fibromyalgia Impact Questionnaire (FIQ\u2010G)","volume":"27","author":"Offenbaecher M","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050932"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360612"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","unstructured":"Aleman\u2010GomezY Melie\u2010GarciaL Valdes\u2010HernandezP.IBASPM: toolbox for automatic parcellation of brain structures. 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