{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:14:08Z","timestamp":1789071248844,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,30]],"date-time":"2008-12-30T00:00:00Z","timestamp":1230595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>IL2RA\/CD25<\/jats:italic>, the gene for interleukin\u20102 receptor \u03b1, is emerging as a general susceptibility gene for autoimmune diseases because of its role in the development and function of regulatory T cells and the association of single\u2010nucleotide polymorphisms (SNPs) within this gene with type 1 diabetes mellitus (DM), Graves' disease, rheumatoid arthritis (RA), and multiple sclerosis (MS). The aim of this study was to determine whether SNPs within the <jats:italic>IL2RA\/CD25<\/jats:italic> gene are associated with juvenile idiopathic arthritis (JIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three SNPs within the <jats:italic>IL2RA\/CD25<\/jats:italic> gene, that previously showed evidence of an association with either RA, MS, or type 1 DM, were selected for genotyping in UK JIA cases (n = 654) and controls (n = 3,849). Data for 1 SNP (rs2104286) were also available from North American JIA cases (n = 747) and controls (n = 1,161). Association analyses were performed using Plink software. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SNP rs2104286 within the <jats:italic>IL2RA\/CD25<\/jats:italic> gene was significantly associated with UK JIA cases (OR for the allele 0.76 [95% CI 0.66\u20130.88], <jats:italic>P<\/jats:italic> for trend = 0.0002). A second SNP (rs41295061) also showed modest evidence for association with JIA (OR 0.80 [95% CI 0.63\u20131.0], <jats:italic>P<\/jats:italic> = 0.05). Association with rs2104286 was convincingly replicated in the North American JIA cohort (OR 0.84 [95% CI 0.65\u20130.99], <jats:italic>P<\/jats:italic> for trend = 0.05). Meta\u2010analysis of the 2 cohorts yielded highly significant evidence of association with JIA (OR 0.76 [95% CI 0.62\u20130.88], <jats:italic>P<\/jats:italic> = 4.9 \u00d7 10<jats:sup>\u22125<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results provide strong evidence that the <jats:italic>IL2RA\/CD25<\/jats:italic> gene represents a JIA susceptibility locus. Further investigation of the gene using both genetic and functional approaches is now required.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.24187","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T21:41:14Z","timestamp":1230759674000},"page":"251-257","source":"Crossref","is-referenced-by-count":90,"title":["Association of the IL2RA\/CD25 gene with juvenile idiopathic 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