{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:20:13Z","timestamp":1787170813264,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Recent genome\u2010wide association studies identified an association between single\u2010nucleotide polymorphisms (SNPs) in the\n                      <jats:italic>C8orf13<\/jats:italic>\n                      region of\n                      <jats:italic>BLK<\/jats:italic>\n                      , the B lymphoid tyrosine kinase gene, with systemic lupus erythematosus (SLE) in Caucasians. The purpose of this study was to evaluate the significance of this region in the genetic background of Japanese patients with SLE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fourteen tag SNPs in the\n                      <jats:italic>C8orf13\u2013BLK<\/jats:italic>\n                      region were genotyped in 327 Japanese patients with SLE and 322 healthy Japanese controls. The population\u2010attributable risk percentage (PAR%) of rs13277113 in Japanese was compared with that in Caucasians as well as with that of other SLE susceptibility genes in Japanese.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      As in Caucasians, rs13277113A demonstrated the strongest association in Japanese (\n                      <jats:italic>P<\/jats:italic>\n                      = 1.73 \u00d7 10\n                      <jats:sup>\u20136<\/jats:sup>\n                      for the genotype frequency,\n                      <jats:italic>P<\/jats:italic>\n                      = 4.75 \u00d7 10\n                      <jats:sup>\u20137<\/jats:sup>\n                      for the allele frequency, odds ratio [OR] 2.44 [95% confidence interval (95% CI) 1.43\u20134.16]). The association in Japanese was consistent with a recessive model (\n                      <jats:italic>P<\/jats:italic>\n                      = 2.74 \u00d7 10\n                      <jats:sup>\u20137<\/jats:sup>\n                      , OR 2.27 [95% CI 1.66\u20133.11]). In contrast to the Caucasian population, this risk allele was the major allele in the Japanese population. Because both the risk allele frequency and the OR were higher in Japanese than in Caucasians, the PAR% of rs13277113 was estimated to be much higher in Japanese (35.4%) than in Caucasians (16.2%), and the second highest among the 6 confirmed SLE susceptibility genes in Japanese.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The association of the\n                      <jats:italic>C8orf13\u2013BLK<\/jats:italic>\n                      region with SLE was replicated in a Japanese population. Contribution of this region to the genetic predisposition to SLE appeared to be greater in Japanese than in Caucasians.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.24246","type":"journal-article","created":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T01:30:47Z","timestamp":1233192647000},"page":"553-558","source":"Crossref","is-referenced-by-count":57,"title":["Replication of the association between the\n                    <i>C8orf13\u2013BLK<\/i>\n                    region and systemic lupus erythematosus in a Japanese population"],"prefix":"10.1002","volume":"60","author":[{"given":"Ikue","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taichi","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akito","family":"Tsutsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Hom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinari","family":"Takasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy W.","family":"Behrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Sumida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"956","article-title":"Association of systemic lupus erythematosus with C8orf13\u2010BLK and ITGAM\u2010ITGAX","volume":"28","author":"Hom G","year":"2008","journal-title":"N Engl J Med"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.81"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)42905-5"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_2_5_6_2","first-page":"379","volume-title":"Approach to gene mapping in complex human diseases","author":"Schildkraut JM","year":"1998"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-1809.2001.6520197.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009749409103059"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10257"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22220"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.1999.530602.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.058917"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem019"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg270"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23216"},{"key":"e_1_2_5_16_2","unstructured":"TahiraT MasumotoM KukitaY HoriuchiT HayashiK. Pooling\u2010based genomewide association study identifies loci for systemic lupus erythematosus [abstract]. Presented at the 57th Annual Meeting of the American Society of Human Genetics;2007Oct 24\u20137; San Diego California. URL:http:\/\/www.ashg.org\/cgi\u2010bin\/ashg07s\/ashg07."}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.24246","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.24246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T16:49:20Z","timestamp":1696956560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.24246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,29]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1002\/art.24246"],"URL":"https:\/\/doi.org\/10.1002\/art.24246","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,29]]}}}