{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T03:46:36Z","timestamp":1769917596601,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,3,30]],"date-time":"2009-03-30T00:00:00Z","timestamp":1238371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We recently reported that RANTES was a key molecule in the pathogenesis of juvenile rheumatoid arthritis (JRA) in a longitudinal cohort. This study was undertaken to investigate genetic associations between the RANTES \u221228 C\/G and \u2212403 G\/A polymorphisms and JRA in a well\u2010documented cohort of patients who were followed up prospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with JRA (n = 107) and healthy children (n = 139) were genotyped through use of a polymerase chain reaction\u2013based assay. Association of the RANTES promoter polymorphisms with results of laboratory tests, clinical variables, outcome after clinical remission, and response to intraarticular triamcinolone injection was evaluated in patients who were followed up for &gt;1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>JRA patients had a significantly higher frequency of the RANTES \u221228 G\/G genotype, as compared with ethnically matched healthy controls. The RANTES \u221228 C\/G polymorphism was associated with the duration of clinical remission, with patients carrying the RANTES \u201328G allele experiencing only 49% of the duration of remission experienced by patients who were RANTES \u221228 C\/C homozygous. The RANTES \u221228 C\/G polymorphism was associated with the duration of clinical response to intraarticular triamcinolone injection, with patients carrying the RANTES \u221228G allele showing shorter duration of clinical response. No significant association between the RANTES \u2212403 G\/A polymorphism and JRA was found in this Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that the RANTES \u221228 C\/G polymorphism represents a genetic risk factor for JRA. It is noteworthy that this RANTES promoter polymorphism was also associated with an early relapse of disease after clinical remission and a shorter duration of clinical response to intraarticular administration of corticosteroids.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.24422","type":"journal-article","created":{"date-parts":[[2009,3,31]],"date-time":"2009-03-31T01:45:08Z","timestamp":1238463908000},"page":"1173-1178","source":"Crossref","is-referenced-by-count":14,"title":["Association of RANTES promoter polymorphism with juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"60","author":[{"given":"Tsung\u2010Chieh","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Chan","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010Long","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21962"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002960100104"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2172"},{"key":"e_1_2_6_5_2","first-page":"419","article-title":"Relationship between serum RANTES levels and radiological progression in rheumatoid arthritis patients treated with methotrexate","volume":"17","author":"Boiardi L","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1998.4590"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.8.4581"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.3.1612"},{"key":"e_1_2_6_9_2","first-page":"391","article-title":"RANTES gene polymorphism in polymyalgia rheumatica, giant cell arteritis and rheumatoid arthritis","volume":"18","author":"Makki RF","year":"2000","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_10_2","first-page":"379","article-title":"RANTES promoter polymorphisms as a genetic risk factor for rheumatoid arthritis in the Chinese","volume":"23","author":"Wang CR","year":"2005","journal-title":"Clin Exp Rheumatol"},{"issue":"2","key":"e_1_2_6_11_2","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"JRA Criteria Subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290216"},{"key":"e_1_2_6_13_2","first-page":"1991","article-title":"Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997","volume":"25","author":"Petty RE","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_6_14_2","first-page":"2290","article-title":"Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritis","volume":"31","author":"Wallace CA","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_6_15_2","first-page":"789","article-title":"Preliminary validation of clinical remission criteria using the OMERACT filter for select categories of juvenile idiopathic arthritis","volume":"33","author":"Wallace CA","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1506"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004694-200007000-00001"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.24422","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.24422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T12:12:27Z","timestamp":1696680747000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.24422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,30]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1002\/art.24422"],"URL":"https:\/\/doi.org\/10.1002\/art.24422","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,30]]}}}