{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:14:28Z","timestamp":1789186468456,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,4,29]],"date-time":"2009-04-29T00:00:00Z","timestamp":1240963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2009,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Beh\u00e7et's disease (BD) is a rare, multisystem inflammatory disorder of unknown cause. Although well\u2010documented in Eastern populations, epidemiologic data is scarce in North American countries. Here we describe the incidence and prevalence of BD in Olmsted County, Minnesota over 45 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified an incidence cohort of subjects age \u226518 years who had a clinical diagnosis of and\/or fulfilled the International Study Group (ISG) criteria for BD from January 1, 1960 to January 1, 2005. Age\u2010 and sex\u2010specific incidence and prevalence were estimated and age\u2010 and sex\u2010adjusted to the 2000 US total population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study population was comprised of 13 subjects with BD; 11 fulfilled ISG criteria between 1960 and 2005. Mean \u00b1 SD age was 31 \u00b1 9 years, and 69% were white. Point prevalence in 2000 was 5.2 per 100,000 population (95% confidence interval [95% CI] 0.64\u20139.84). The overall annual age\u2010 and sex\u2010adjusted incidence of BD was 0.38 per 100,000 population (95% CI 0.17\u20130.59), with a higher incidence in women (0.51 per 100,000; 95% CI 0.17\u20130.84) than in men (0.26 per 100,000; 95% CI 0.004\u20130.52). Dermatologic lesions included oral ulcers (100%), genital ulcers (62%), erythema nodosum (46%), and papulopustular lesions (54%). Ocular lesions, vascular complications, and central nervous system involvement were present in 8, 3, and 3 subjects, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study shows an overall incidence of 0.38 per 100,000 population, which is comparable with other Western populations. The prevalence of 5.2 per 100,000 population is similar to estimates reported in Western countries, but lower than that in countries along the Silk Road.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.24423","type":"journal-article","created":{"date-parts":[[2009,4,29]],"date-time":"2009-04-29T06:48:06Z","timestamp":1240987686000},"page":"600-604","source":"Crossref","is-referenced-by-count":224,"title":["Epidemiology and clinical characteristics of beh\u00e7et's disease in the US: A population\u2010based study"],"prefix":"10.1002","volume":"61","author":[{"given":"Kenneth T.","family":"Calamia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floranne C.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Icen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia S.","family":"Crowson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherine E.","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal Maradit","family":"Kremers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,29]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"488","article-title":"Epidemiology of Adamantiades\u2010Beh\u00e7et's disease","volume":"150","author":"Zouboulis CC","year":"1999","journal-title":"Ann Med Interne (Paris)"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910213411707"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1997.38.6.411"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0436"},{"key":"e_1_2_7_6_2","series-title":"Rheumatology","first-page":"1","author":"Yazici H","year":"1998"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.123554"},{"issue":"4","key":"e_1_2_7_8_2","first-page":"S58","article-title":"Beh\u00e7et's disease in Tunisia: demographic, clinical and genetic aspects in 260 patients","volume":"25","author":"Houman MH","year":"2007","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01613.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/08830189709116846"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/03009740600991927"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01893.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(98)00011-1"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22500"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.1999.540301.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.68.801.566"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1076\/ocii.10.1.53.10326"},{"key":"e_1_2_7_18_2","first-page":"1","article-title":"Beh\u00e7et's disease","volume":"53","author":"Calamia K","year":"2004","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000247411.59213.bb"},{"key":"e_1_2_7_20_2","first-page":"538","article-title":"Adamantiades\u2010Beh\u00e7et's disease in Germany: data of the German registry in 1966","volume":"63","author":"Zouboulis CC","year":"1996","journal-title":"Rev Rhum Engl Ed"},{"key":"e_1_2_7_21_2","volume-title":"Beh\u00e7et's disease","author":"Nakae K","year":"1993"},{"key":"e_1_2_7_22_2","first-page":"229","article-title":"Summary of international symposium on Beh\u00e7et's disease: Istanbul, September 29\u201330, 1977","volume":"5","author":"O'Duffy JD","year":"1978","journal-title":"J Rheumatol"},{"key":"e_1_2_7_23_2","first-page":"15","volume-title":"Beh\u00e7et's disease: a contemporary synopsis","author":"Teter MS","year":"1988"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199401000-00007"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.4065\/71.3.266"},{"key":"e_1_2_7_26_2","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease","volume":"335","author":"International Study Group for Beh\u00e7et's disease","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_7_27_2","unstructured":"SchroederDJ OffordKP.A SAS macro which utilizes local and reference population counts appropriate for incidence prevalence and mortality rate calculations in Rochester and Olmsted County Minnesota. 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